Evidence map›Paper›PMID 36917703›Full record

ArticleNano letters2023

Interactions of Graphene Oxide and Few-Layer Graphene with the Blood-Brain Barrier.

Valentina Castagnola, Lieselot Deleye, Alice Podestà, Edra Jaho, Fabrizio Loiacono, Doriana Debellis, Martina Trevisani, Dinu Zinovie Ciobanu, Andrea Armirotti, Francesco Pisani and 5 more

Abstract read
In one paragraph

Article in Nano letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Valentina CastagnolaCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi 10, 16132 Genova, Italy.
Lieselot DeleyeCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi 10, 16132 Genova, Italy.
Alice PodestàCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi 10, 16132 Genova, Italy.ORCID 0000-0001-5837-832X
Edra JahoCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi 10, 16132 Genova, Italy.
Fabrizio LoiaconoIRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy.
Doriana DebellisElectron Microscopy Facility, Istituto Italiano di Tecnologia, Via Morego, 30, 16163 Genova, Italy.
Martina TrevisaniCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi 10, 16132 Genova, Italy.
Dinu Zinovie CiobanuAnalytical Chemistry Lab, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.
Andrea ArmirottiAnalytical Chemistry Lab, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.ORCID 0000-0002-3766-8755
Francesco PisaniCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi 10, 16132 Genova, Italy.
Emmanuel FlahautCIRIMAT, UMR 5085, CNRS-INP-UPS, Université Toulouse 3 Paul Sabatier, 118 route de Narbonne, F-31062 Toulouse cedex 9, France.ORCID 0000-0001-8344-6902
Ester VazquezInstituto Regional de Investigación Científica Aplicada (IRICA), Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain.ORCID 0000-0003-3223-8024
Mattia BraminiCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi 10, 16132 Genova, Italy.ORCID 0000-0002-0381-9391
Fabrizia CescaCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi 10, 16132 Genova, Italy.ORCID 0000-0003-2190-6314
Fabio BenfenatiCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi 10, 16132 Genova, Italy.ORCID 0000-0002-0653-8368

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thanks to their biocompatibility and high cargo capability, graphene-based materials (GRMs) might represent an ideal brain delivery system. The capability of GRMs to reach the brain has mainly been investigated

Indexed as

Blood-Brain BarrierGraphiteAnimalsBrainEndothelial CellsHumansMicegraphene oxideGraphiteassembloidsblood−brain barriergraphenetight junctionsuptake pathways

Identifiers

PMID36917703
PMCPMC10103300

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.