Evidence map›Paper›PMID 36917701›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2023

Hydrogen Bonding Parameters by Rapid Colorimetric Assessment: Evaluation of Structural Components Found in Biological Ligands and Organocatalysts.

Hanna F Roenfanz, Thomas J Paniak, Cameron B Berlin, Van Tran, Karol R Francisco, Pierrik Lassalas, Anisha Devas, Olivia Landes, Avalon Rosenberger, Madeline E Rotella and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hanna F RoenfanzDepartment of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA.ORCID http://orcid.org/0000-0002-0990-0932
Thomas J PaniakDepartment of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA.ORCID http://orcid.org/0000-0003-2331-1971
Cameron B BerlinDepartment of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA.
Van TranDepartment of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA.
Karol R FranciscoDepartment of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID http://orcid.org/0000-0001-9742-8801
Pierrik LassalasDepartment of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA.ORCID http://orcid.org/0000-0001-9838-6973
Anisha DevasDepartment of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA.
Olivia LandesDepartment of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA.
Avalon RosenbergerDepartment of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA.
Madeline E RotellaDepartment of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA.ORCID http://orcid.org/0000-0002-7973-2452
Carlo BallatoreSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID http://orcid.org/0000-0002-2718-3850
Marisa C KozlowskiDepartment of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA.ORCID http://orcid.org/0000-0002-4225-7125

Funding

RESEARCH IN INFECTIOUS DISEASEST32AI007036 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR · 1985 to 2025
$9.2M
Computation and Development of New, Enabling Synthetic MethodsR35GM131902 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Marisa C Kozlowski · 2019 to 2026
$4.5M
Computational Methods for Selective CatalysisR01GM087605 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KOZLOWSKI, MARISA C · 2010 to 2019
$2.4M
Targeting Nucleic Acid Junctions with Small MoleculesR01GM118510 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI CHENOWETH, DAVID MICHAEL · 2016 to 2020
$1.6M
NIAID NIH HHS T32 AI007036NIGMS NIH HHS R01 GM087605NIGMS NIH HHS R01 GM118510NIGMS NIH HHS R35 GM131902NIH HHS 3R01GM087605-06S1NIH HHS 3R01GM118510-03S1NIH HHS R35 GM131902
6 · The paper itself

Abstract

Hydrogen bonding is a key molecular interaction in biological processes, drug delivery, and catalysis. This report describes a high throughput UV-Vis spectroscopic method to measure hydrogen bonding capacity using a pyrazinone sensor. This colormetric sensor reversibly binds to a hydrogen bond donor, resulting in a blue shift as additional equivalents of donor are added. Titration with excess equivalents of donor is used to determine the binding coefficient, ln(K

Indexed as

ColorimetryHydrogen BondingLigandsLigandsbioisoterescolorimetric sensorscolorimetryhydrogen bondingorganocatalysts

Identifiers

PMID36917701
PMCPMC10363249

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.