Evidence map›Paper›PMID 36917669›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Functional SARS-CoV-2 cross-reactive CD4

Marion Humbert, Anna Olofsson, David Wullimann, Julia Niessl, Emma B Hodcroft, Curtis Cai, Yu Gao, Ebba Sohlberg, Robert Dyrdak, Flora Mikaeloff and 10 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Human T Cell Responses to Flavivirus Vaccines.European journal of immunology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Human coronavirus OC43-elicited CD4Nature communications · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 4 countries.

Marion HumbertDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.ORCID 0000-0002-1710-1479
Anna OlofssonDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.
David WullimannCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.ORCID 0000-0003-1632-0394
Julia NiesslCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.ORCID 0000-0001-8852-1924
Emma B HodcroftInstitute of Social and Preventive Medicine, University of Bern, Bern 3012, Switzerland.
Curtis CaiCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.ORCID 0000-0002-3490-4361
Yu GaoCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.
Ebba SohlbergCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.ORCID 0000-0003-1942-0040
Robert DyrdakDepartment of Clinical Microbiology, Karolinska University Hospital, 171 76 Stockholm, Sweden.
Flora MikaeloffDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.
Ujjwal NeogiDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.ORCID 0000-0002-0844-3338
Jan AlbertDepartment of Clinical Microbiology, Karolinska University Hospital, 171 76 Stockholm, Sweden.ORCID 0000-0001-9020-0521
Karl-Johan MalmbergCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.
Fridtjof Lund-JohansenDepartment of Immunology, Institute of Clinical Medicine, Oslo University Hospital, 0372 Oslo, Norway.ORCID 0000-0002-2445-1258
Soo AlemanUnit for Infectious Diseases and Dermatology, I73, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden.ORCID 0000-0003-0461-4870
Linda Björkhem-BergmanDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 141 83 Huddinge, Sweden.
Maria C JenmalmDivision of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, 581 83 Linköping, Sweden.ORCID 0000-0002-2117-5366
Hans-Gustaf LjunggrenCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.ORCID 0000-0003-0908-7387
Marcus BuggertCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 141 52 Huddinge, Sweden.ORCID 0000-0003-0633-1719
Annika C KarlssonDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.ORCID 0000-0002-2028-8393
Karolinska Institutet · SEKarolinska University Hospital · SEOslo University Hospital · NOLinköping University · SESwedish Foundation for Strategic Research · SEUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pre-existing SARS-CoV-2-reactive T cells have been identified in SARS-CoV-2-unexposed individuals, potentially modulating COVID-19 and vaccination outcomes. Here, we provide evidence that functional cross-reactive memory CD4

Indexed as

COVID-19Epstein-Barr Virus InfectionsAdultAgedAged, 80 and overAntibodies, ViralCD4-Positive T-LymphocytesChildChild, PreschoolCross ReactionsHerpesvirus 4, HumanHumansMiddle AgedSARS-CoV-2Spike Glycoprotein, CoronavirusT-LymphocytesAntibodies, ViralSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2age groupscross-protectionhuman coronavirus OC43SARS-CoV-2T cell specificity

Identifiers

PMID36917669
PMCPMC10041119
OpenAlexW4324133213

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.