Evidence map›Paper›PMID 36917423›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2023

Linc-ROR Promotes EMT by Targeting miR-204-5p/SMAD4 in Endometriosis.

Mingyu Yi, Sixue Wang, Xinyue Zhang, Li Jiang, Xiaomeng Xia, Tingting Zhang, Xiaoling Fang

Abstract read
PubMed Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mingyu YiDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Sixue WangDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Xinyue ZhangDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Li JiangDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Xiaomeng XiaDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Tingting ZhangDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Xiaoling FangDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China. fxlfxl0510@csu.edu.cn.ORCID 0000-0001-6005-9598
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometriosis (EMs) is a systemic and chronic disease with cancer-like feature, namely, distant implantation, which caused heavy healthy burden of nearly 200 million females. LncRNAs have been proved as new modulators in epithelial-mesenchymal transition (EMT) and EMs. Quantitative real-time PCR was conducted to measure the expression level of long intergenic non-protein coding RNA, regulator of reprogramming (Linc-ROR), and miR-204-5p in ectopic endometrium (n = 25), eutopic endometrium (n = 20), and natural control endometrium (n = 22). Overexpression of Linc-ROR, knockdown or overexpression of miR-204-5p in End1/E6E7 and Ishikawa cells, was conducted to detect the function of Linc-ROR and miR-204-5p in EMs. Furthermore, luciferase reports were used to confirm the combination of Linc-ROR and miR-204-5p and the combination between miR-204-5p and SMAD4. Cell-Counting Kit-8, EdU assay, transwell assays, and Western blotting were used to detect the function of Linc-ROR and miR-204-5p in EMs cancer-like behaviors and EMT process. Linc-ROR was up-regulated in ectopic endometrium. Overexpressed Linc-ROR promotes cell proliferation, invasion, and EMT process. Linc-ROR regulated the EMT process, cellular proliferation, and invasion of EMs via binding to miR-204-5p. In addition, overexpression of Linc-ROR up-regulated SMAD4, a target protein of miR-204-5p, with which regulated EMT process and cancer-like behaviors in EMs together. Linc-ROR/miR-204-5p/SMAD4 axis plays a vital role in regulation EMT process in EMs, which might become a novel therapeutic targets and powerful biomarkers in EMs therapy.

Indexed as

EndometriosisMicroRNAsRNA, Long NoncodingBiomarkersCell Line, TumorCell MovementCell ProliferationEpithelial-Mesenchymal TransitionFemaleHumansSmad4 ProteinBiomarkersMicroRNAsMIRN204 microRNA, humanRNA, Long NoncodingSmad4 ProteinSMAD4 protein, humanceRNAEMTEndometriosisLinc-RORmiR-204-5pSMAD4

Identifiers

PMID36917423
OpenAlexW4324129223

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.