Evidence map›Paper›PMID 36916910›Full record

ArticlemBio2023

CRISPR Screens Identify

Shruthi Krishnamurthy, Parag Maru, Yifan Wang, Mebratu A Bitew, Debanjan Mukhopadhyay, Yoshiki Yamaryo-Botté, Tatiana C Paredes-Santos, Lamba O Sangaré, Christopher Swale, Cyrille Y Botté and 1 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Surface antigen SAG1 mediatesInfection and immunity · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Applications of CRISPR in Parasitology.Current pharmaceutical biotechnology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. SPARK regulates AGC kinases central to thebioRxiv : the preprint server for biology · 2024
    Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. A Combination of Four Nuclear Targeted Effectors ProtectsbioRxiv : the preprint server for biology · 2023
    Article
  18. ThemSphere · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Shruthi KrishnamurthyDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Parag MaruDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Yifan WangDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Mebratu A BitewDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Debanjan MukhopadhyayDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Yoshiki Yamaryo-BottéApicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, INSERM U1209, Université Grenoble Alpes, Batiment Jean Roget, Grenoble, France.
Tatiana C Paredes-SantosDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Lamba O SangaréDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Christopher SwaleTeam Host-Pathogen Interactions and Immunity to Infection, Institute for Advanced Biosciences (IAB), INSERM U1209, CNRS UMR5309, University Grenoble Alpes, Grenoble, France.
Cyrille Y BottéApicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, INSERM U1209, Université Grenoble Alpes, Batiment Jean Roget, Grenoble, France.ORCID 0000-0002-2245-536X
Jeroen P J SaeijDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.ORCID 0000-0003-0289-7109
University of California, Davis · USCentre National de la Recherche Scientifique · FRThe Francis Crick Institute · GB

Funding

Genome-wide CRISPR/Cas9-mediated loss-of-function screens to identify Toxoplasma genes that determine fitness in gamma interferon-stimulated human cellsR21AI149071 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SAEIJ, JEROEN · 2020 to 2021
$432k
Synthetic lethality screens in a nutrient sensitized Toxoplasma strain to identify novel proteins that mediate nutrient acquisition in chronic Toxoplasma infection.R21AI150326 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SAEIJ, JEROEN · 2020 to 2021
$432k
American Heart Association-American Stroke Association 18POST34060141NIAID NIH HHS R21 AI149071NIAID NIH HHS R21 AI150326NIAID NIH HHS R21-AI150326
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ParasitesToxoplasmaAnimalsClustered Regularly Interspaced Short Palindromic RepeatsHumansInterferon-gammaMiceProtozoan ProteinsVirulenceInterferon-gammaProtozoan ProteinsCRISPR screeneffector functionshost-pathogen interactionsinterferonsToxoplasma gondii

Identifiers

PMID36916910
PMCPMC10128063
OpenAlexW4324130287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.