Evidence map›Paper›PMID 36916896›Full record

ReviewRadiology2023

How to Critically Appraise and Interpret Systematic Reviews and Meta-Analyses of Diagnostic Accuracy: A User Guide.

Robert A Frank, Jean-Paul Salameh, Nayaar Islam, Bada Yang, Mohammad Hassan Murad, Reem Mustafa, Mariska Leeflang, Patrick M Bossuyt, Yemisi Takwoingi, Penny Whiting and 6 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Robert A Frank *From the Department of Radiology, University of Ottawa, The Ottawa Hospital Civic Campus, 1053 Carling Ave, Room c159, Ottawa, ON, Canada K1Y 4E9 (R.A.F., M.D.F.M.); Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada (J.P.S.); Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada (N.I., M.H.M., H.D., S.E., B.H.); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (B.Y.); Evidence-Based Practice Center, Mayo Clinic, Rochester, Minn (M.H.M.); Department of Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Mo (R.M.); Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands (M.L., P.M.B.); Amsterdam Public Health, Amsterdam, the Netherlands (P.M.B.); Institute of Applied Health Research, University of Birmingham, Birmingham, UK (Y.T.); NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK (Y.T.); Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK (P.W.); Department of Radiology, NYU Langone Health, New York, NY (S.K.K.); and Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada (B.L.).ORCID 0000-0002-7963-3040
Jean-Paul Salameh *From the Department of Radiology, University of Ottawa, The Ottawa Hospital Civic Campus, 1053 Carling Ave, Room c159, Ottawa, ON, Canada K1Y 4E9 (R.A.F., M.D.F.M.); Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada (J.P.S.); Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada (N.I., M.H.M., H.D., S.E., B.H.); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (B.Y.); Evidence-Based Practice Center, Mayo Clinic, Rochester, Minn (M.H.M.); Department of Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Mo (R.M.); Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands (M.L., P.M.B.); Amsterdam Public Health, Amsterdam, the Netherlands (P.M.B.); Institute of Applied Health Research, University of Birmingham, Birmingham, UK (Y.T.); NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK (Y.T.); Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK (P.W.); Department of Radiology, NYU Langone Health, New York, NY (S.K.K.); and Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada (B.L.).ORCID 0000-0002-4105-2056
Nayaar IslamFrom the Department of Radiology, University of Ottawa, The Ottawa Hospital Civic Campus, 1053 Carling Ave, Room c159, Ottawa, ON, Canada K1Y 4E9 (R.A.F., M.D.F.M.); Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada (J.P.S.); Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada (N.I., M.H.M., H.D., S.E., B.H.); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (B.Y.); Evidence-Based Practice Center, Mayo Clinic, Rochester, Minn (M.H.M.); Department of Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Mo (R.M.); Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands (M.L., P.M.B.); Amsterdam Public Health, Amsterdam, the Netherlands (P.M.B.); Institute of Applied Health Research, University of Birmingham, Birmingham, UK (Y.T.); NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK (Y.T.); Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK (P.W.); Department of Radiology, NYU Langone Health, New York, NY (S.K.K.); and Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada (B.L.).ORCID 0000-0002-1159-7629
Bada YangFrom the Department of Radiology, University of Ottawa, The Ottawa Hospital Civic Campus, 1053 Carling Ave, Room c159, Ottawa, ON, Canada K1Y 4E9 (R.A.F., M.D.F.M.); Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada (J.P.S.); Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada (N.I., M.H.M., H.D., S.E., B.H.); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (B.Y.); Evidence-Based Practice Center, Mayo Clinic, Rochester, Minn (M.H.M.); Department of Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Mo (R.M.); Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands (M.L., P.M.B.); Amsterdam Public Health, Amsterdam, the Netherlands (P.M.B.); Institute of Applied Health Research, University of Birmingham, Birmingham, UK (Y.T.); NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK (Y.T.); Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK (P.W.); Department of Radiology, NYU Langone Health, New York, NY (S.K.K.); and Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada (B.L.).ORCID 0000-0002-9317-4995
Mohammad Hassan MuradFrom the Department of Radiology, University of Ottawa, The Ottawa Hospital Civic Campus, 1053 Carling Ave, Room c159, Ottawa, ON, Canada K1Y 4E9 (R.A.F., M.D.F.M.); Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada (J.P.S.); Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada (N.I., M.H.M., H.D., S.E., B.H.); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (B.Y.); Evidence-Based Practice Center, Mayo Clinic, Rochester, Minn (M.H.M.); Department of Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Mo (R.M.); Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands (M.L., P.M.B.); Amsterdam Public Health, Amsterdam, the Netherlands (P.M.B.); Institute of Applied Health Research, University of Birmingham, Birmingham, UK (Y.T.); NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK (Y.T.); Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK (P.W.); Department of Radiology, NYU Langone Health, New York, NY (S.K.K.); and Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada (B.L.).ORCID 0000-0001-5502-5975
Reem MustafaFrom the Department of Radiology, University of Ottawa, The Ottawa Hospital Civic Campus, 1053 Carling Ave, Room c159, Ottawa, ON, Canada K1Y 4E9 (R.A.F., M.D.F.M.); Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada (J.P.S.); Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada (N.I., M.H.M., H.D., S.E., B.H.); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (B.Y.); Evidence-Based Practice Center, Mayo Clinic, Rochester, Minn (M.H.M.); Department of Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Mo (R.M.); Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands (M.L., P.M.B.); Amsterdam Public Health, Amsterdam, the Netherlands (P.M.B.); Institute of Applied Health Research, University of Birmingham, Birmingham, UK (Y.T.); NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK (Y.T.); Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK (P.W.); Department of Radiology, NYU Langone Health, New York, NY (S.K.K.); and Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada (B.L.).ORCID 0000-0002-2091-0875
Mariska LeeflangFrom the Department of Radiology, University of Ottawa, The Ottawa Hospital Civic Campus, 1053 Carling Ave, Room c159, Ottawa, ON, Canada K1Y 4E9 (R.A.F., M.D.F.M.); Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada (J.P.S.); Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada (N.I., M.H.M., H.D., S.E., B.H.); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (B.Y.); Evidence-Based Practice Center, Mayo Clinic, Rochester, Minn (M.H.M.); Department of Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Mo (R.M.); Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands (M.L., P.M.B.); Amsterdam Public Health, Amsterdam, the Netherlands (P.M.B.); Institute of Applied Health Research, University of Birmingham, Birmingham, UK (Y.T.); NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK (Y.T.); Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK (P.W.); Department of Radiology, NYU Langone Health, New York, NY (S.K.K.); and Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada (B.L.).ORCID 0000-0001-5960-0471
Patrick M BossuytFrom the Department of Radiology, University of Ottawa, The Ottawa Hospital Civic Campus, 1053 Carling Ave, Room c159, Ottawa, ON, Canada K1Y 4E9 (R.A.F., M.D.F.M.); Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada (J.P.S.); Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada (N.I., M.H.M., H.D., S.E., B.H.); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (B.Y.); Evidence-Based Practice Center, Mayo Clinic, Rochester, Minn (M.H.M.); Department of Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Mo (R.M.); Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands (M.L., P.M.B.); Amsterdam Public Health, Amsterdam, the Netherlands (P.M.B.); Institute of Applied Health Research, University of Birmingham, Birmingham, UK (Y.T.); NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK (Y.T.); Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK (P.W.); Department of Radiology, NYU Langone Health, New York, NY (S.K.K.); and Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada (B.L.).ORCID 0000-0003-4427-0128
Yemisi TakwoingiFrom the Department of Radiology, University of Ottawa, The Ottawa Hospital Civic Campus, 1053 Carling Ave, Room c159, Ottawa, ON, Canada K1Y 4E9 (R.A.F., M.D.F.M.); Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada (J.P.S.); Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada (N.I., M.H.M., H.D., S.E., B.H.); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (B.Y.); Evidence-Based Practice Center, Mayo Clinic, Rochester, Minn (M.H.M.); Department of Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Mo (R.M.); Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands (M.L., P.M.B.); Amsterdam Public Health, Amsterdam, the Netherlands (P.M.B.); Institute of Applied Health Research, University of Birmingham, Birmingham, UK (Y.T.); NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK (Y.T.); Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK (P.W.); Department of Radiology, NYU Langone Health, New York, NY (S.K.K.); and Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada (B.L.).ORCID 0000-0002-5828-9746
Penny WhitingFrom the Department of Radiology, University of Ottawa, The Ottawa Hospital Civic Campus, 1053 Carling Ave, Room c159, Ottawa, ON, Canada K1Y 4E9 (R.A.F., M.D.F.M.); Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada (J.P.S.); Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada (N.I., M.H.M., H.D., S.E., B.H.); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (B.Y.); Evidence-Based Practice Center, Mayo Clinic, Rochester, Minn (M.H.M.); Department of Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Mo (R.M.); Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands (M.L., P.M.B.); Amsterdam Public Health, Amsterdam, the Netherlands (P.M.B.); Institute of Applied Health Research, University of Birmingham, Birmingham, UK (Y.T.); NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK (Y.T.); Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK (P.W.); Department of Radiology, NYU Langone Health, New York, NY (S.K.K.); and Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada (B.L.).ORCID 0000-0003-1138-5682
Haben DawitFrom the Department of Radiology, University of Ottawa, The Ottawa Hospital Civic Campus, 1053 Carling Ave, Room c159, Ottawa, ON, Canada K1Y 4E9 (R.A.F., M.D.F.M.); Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada (J.P.S.); Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada (N.I., M.H.M., H.D., S.E., B.H.); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (B.Y.); Evidence-Based Practice Center, Mayo Clinic, Rochester, Minn (M.H.M.); Department of Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Mo (R.M.); Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands (M.L., P.M.B.); Amsterdam Public Health, Amsterdam, the Netherlands (P.M.B.); Institute of Applied Health Research, University of Birmingham, Birmingham, UK (Y.T.); NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK (Y.T.); Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK (P.W.); Department of Radiology, NYU Langone Health, New York, NY (S.K.K.); and Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada (B.L.).ORCID 0000-0002-8052-4124
Stella K KangFrom the Department of Radiology, University of Ottawa, The Ottawa Hospital Civic Campus, 1053 Carling Ave, Room c159, Ottawa, ON, Canada K1Y 4E9 (R.A.F., M.D.F.M.); Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada (J.P.S.); Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada (N.I., M.H.M., H.D., S.E., B.H.); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (B.Y.); Evidence-Based Practice Center, Mayo Clinic, Rochester, Minn (M.H.M.); Department of Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Mo (R.M.); Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands (M.L., P.M.B.); Amsterdam Public Health, Amsterdam, the Netherlands (P.M.B.); Institute of Applied Health Research, University of Birmingham, Birmingham, UK (Y.T.); NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK (Y.T.); Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK (P.W.); Department of Radiology, NYU Langone Health, New York, NY (S.K.K.); and Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada (B.L.).
Sanam EbrahimzadehFrom the Department of Radiology, University of Ottawa, The Ottawa Hospital Civic Campus, 1053 Carling Ave, Room c159, Ottawa, ON, Canada K1Y 4E9 (R.A.F., M.D.F.M.); Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada (J.P.S.); Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada (N.I., M.H.M., H.D., S.E., B.H.); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (B.Y.); Evidence-Based Practice Center, Mayo Clinic, Rochester, Minn (M.H.M.); Department of Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Mo (R.M.); Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands (M.L., P.M.B.); Amsterdam Public Health, Amsterdam, the Netherlands (P.M.B.); Institute of Applied Health Research, University of Birmingham, Birmingham, UK (Y.T.); NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK (Y.T.); Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK (P.W.); Department of Radiology, NYU Langone Health, New York, NY (S.K.K.); and Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada (B.L.).ORCID 0000-0003-3890-1683
Brooke LevisFrom the Department of Radiology, University of Ottawa, The Ottawa Hospital Civic Campus, 1053 Carling Ave, Room c159, Ottawa, ON, Canada K1Y 4E9 (R.A.F., M.D.F.M.); Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada (J.P.S.); Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada (N.I., M.H.M., H.D., S.E., B.H.); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (B.Y.); Evidence-Based Practice Center, Mayo Clinic, Rochester, Minn (M.H.M.); Department of Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Mo (R.M.); Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands (M.L., P.M.B.); Amsterdam Public Health, Amsterdam, the Netherlands (P.M.B.); Institute of Applied Health Research, University of Birmingham, Birmingham, UK (Y.T.); NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK (Y.T.); Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK (P.W.); Department of Radiology, NYU Langone Health, New York, NY (S.K.K.); and Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada (B.L.).ORCID 0000-0002-4310-3689
Brian HuttonFrom the Department of Radiology, University of Ottawa, The Ottawa Hospital Civic Campus, 1053 Carling Ave, Room c159, Ottawa, ON, Canada K1Y 4E9 (R.A.F., M.D.F.M.); Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada (J.P.S.); Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada (N.I., M.H.M., H.D., S.E., B.H.); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (B.Y.); Evidence-Based Practice Center, Mayo Clinic, Rochester, Minn (M.H.M.); Department of Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Mo (R.M.); Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands (M.L., P.M.B.); Amsterdam Public Health, Amsterdam, the Netherlands (P.M.B.); Institute of Applied Health Research, University of Birmingham, Birmingham, UK (Y.T.); NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK (Y.T.); Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK (P.W.); Department of Radiology, NYU Langone Health, New York, NY (S.K.K.); and Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada (B.L.).ORCID 0000-0001-5662-8647
Matthew D F McInnesFrom the Department of Radiology, University of Ottawa, The Ottawa Hospital Civic Campus, 1053 Carling Ave, Room c159, Ottawa, ON, Canada K1Y 4E9 (R.A.F., M.D.F.M.); Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada (J.P.S.); Clinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada (N.I., M.H.M., H.D., S.E., B.H.); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (B.Y.); Evidence-Based Practice Center, Mayo Clinic, Rochester, Minn (M.H.M.); Department of Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, Mo (R.M.); Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands (M.L., P.M.B.); Amsterdam Public Health, Amsterdam, the Netherlands (P.M.B.); Institute of Applied Health Research, University of Birmingham, Birmingham, UK (Y.T.); NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK (Y.T.); Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK (P.W.); Department of Radiology, NYU Langone Health, New York, NY (S.K.K.); and Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada (B.L.).ORCID 0000-0001-8404-4075

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systematic reviews of diagnostic accuracy studies can provide the best available evidence to inform decisions regarding the use of a diagnostic test. In this guide, the authors provide a practical approach for clinicians to appraise diagnostic accuracy systematic reviews and apply their results to patient care. The first step is to identify an appropriate systematic review with a research question matching the clinical scenario. The user should evaluate the rigor of the review methods to evaluate its credibility (Did the review use clearly defined eligibility criteria, a comprehensive search strategy, structured data collection, risk of bias and applicability appraisal, and appropriate meta-analysis methods?). If the review is credible, the next step is to decide whether the diagnostic performance is adequate for clinical use (Do sensitivity and specificity estimates exceed the threshold that makes them useful in clinical practice? Are these estimates sufficiently precise? Is variability in the estimates of diagnostic accuracy across studies explained?). Diagnostic accuracy systematic reviews that are judged to be credible and provide diagnostic accuracy estimates with sufficient certainty and relevance are the most useful to inform patient care. This review discusses comparative, noncomparative, and emerging approaches to systematic reviews of diagnostic accuracy using a clinical scenario and examples based on recent publications.

Indexed as

DiagnosisMeta-Analysis as TopicSystematic Reviews as TopicHumansSensitivity and Specificity

Identifiers

PMID36916896
PMCPMC10140638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.