Evidence map›Paper›PMID 36916889›Full record

ArticleRadiology2023

Acetazolamide-augmented BOLD MRI to Assess Whole-Brain Cerebrovascular Reactivity in Chronic Steno-occlusive Disease Using Principal Component Analysis.

Siddhant Dogra, Xiuyuan Wang, Alejandro Gupta, Jelle Veraart, Koto Ishida, Deqiang Qiu, Seena Dehkharghani

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Siddhant DograFrom the Departments of Radiology (S. Dogra, A.G., J.V., S. Dehkharghani) and Neurology (K.I., S. Dehkharghani), New York University Langone Health, 660 First Ave, New York, NY 10016; Department of Radiology, Weill Cornell Medical College, New York, NY (X.W.); and Department of Radiology and Imaging Sciences, Emory University, Atlanta, Ga (D.Q.).ORCID 0000-0003-2386-7849
Xiuyuan WangFrom the Departments of Radiology (S. Dogra, A.G., J.V., S. Dehkharghani) and Neurology (K.I., S. Dehkharghani), New York University Langone Health, 660 First Ave, New York, NY 10016; Department of Radiology, Weill Cornell Medical College, New York, NY (X.W.); and Department of Radiology and Imaging Sciences, Emory University, Atlanta, Ga (D.Q.).ORCID 0000-0001-6356-3386
Alejandro GuptaFrom the Departments of Radiology (S. Dogra, A.G., J.V., S. Dehkharghani) and Neurology (K.I., S. Dehkharghani), New York University Langone Health, 660 First Ave, New York, NY 10016; Department of Radiology, Weill Cornell Medical College, New York, NY (X.W.); and Department of Radiology and Imaging Sciences, Emory University, Atlanta, Ga (D.Q.).ORCID 0000-0002-3366-5346
Jelle VeraartFrom the Departments of Radiology (S. Dogra, A.G., J.V., S. Dehkharghani) and Neurology (K.I., S. Dehkharghani), New York University Langone Health, 660 First Ave, New York, NY 10016; Department of Radiology, Weill Cornell Medical College, New York, NY (X.W.); and Department of Radiology and Imaging Sciences, Emory University, Atlanta, Ga (D.Q.).ORCID 0000-0003-0781-0420
Koto IshidaFrom the Departments of Radiology (S. Dogra, A.G., J.V., S. Dehkharghani) and Neurology (K.I., S. Dehkharghani), New York University Langone Health, 660 First Ave, New York, NY 10016; Department of Radiology, Weill Cornell Medical College, New York, NY (X.W.); and Department of Radiology and Imaging Sciences, Emory University, Atlanta, Ga (D.Q.).ORCID 0000-0003-3856-9684
Deqiang QiuFrom the Departments of Radiology (S. Dogra, A.G., J.V., S. Dehkharghani) and Neurology (K.I., S. Dehkharghani), New York University Langone Health, 660 First Ave, New York, NY 10016; Department of Radiology, Weill Cornell Medical College, New York, NY (X.W.); and Department of Radiology and Imaging Sciences, Emory University, Atlanta, Ga (D.Q.).ORCID 0000-0001-8375-1755
Seena DehkharghaniFrom the Departments of Radiology (S. Dogra, A.G., J.V., S. Dehkharghani) and Neurology (K.I., S. Dehkharghani), New York University Langone Health, 660 First Ave, New York, NY 10016; Department of Radiology, Weill Cornell Medical College, New York, NY (X.W.); and Department of Radiology and Imaging Sciences, Emory University, Atlanta, Ga (D.Q.).ORCID 0000-0002-3141-1094
Cornell University · US

Funding

The Emory Healthy Brain Study: Discovering Predictive Biomarkers for Alzheimer's DiseaseR01AG070937 · NIA · EMORY UNIVERSITY · PI LAH, JAMES J · 2021 to 2025
$35.2M
The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI Amy D Rodriguez · 2020 to 2026
$29.0M
Cerebral hemodynamic impairment in symptomatic and asymptomatic Alzheimer's DiseaseR01AG072603 · NIA · EMORY UNIVERSITY · PI Deqiang Qiu · 2022 to 2026
$3.8M
Fast multiparametric MR imaging as early biomarkers of Alzheimer's DiseaseR21AG064405 · NIA · EMORY UNIVERSITY · PI QIU, DEQIANG · 2019 to 2020
$429k
NIA NIH HHS P30 AG066511NIA NIH HHS R01 AG070937NIA NIH HHS R01 AG072603NIA NIH HHS R21 AG064405
6 · The paper itself

Abstract

Background Exhaustion of cerebrovascular reactivity (CVR) portends increased stroke risk. Acetazolamide-augmented blood oxygenation level-dependent (BOLD) MRI has been used to estimate CVR, but low signal-to-noise conditions relegate its use to terminal CVR (CVR

Indexed as

AcetazolamideCerebrovascular DisordersBrainCerebrovascular CirculationHumansMagnetic Resonance ImagingMaleMiddle AgedPrincipal Component AnalysisRetrospective StudiesAcetazolamide

Identifiers

PMID36916889
PMCPMC10140639
OpenAlexW4324129765

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.