ArticleeLife2023
Neural circuits underlying habituation of visually evoked escape behaviors in larval zebrafish.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Hoverfly responses to looming stimuli depend on elevation and speed.The Journal of experimental biology · 2026Article
- Visual Threat Location Impacts Brain-Wide Visual Adaptation Networks.The Journal of comparative neurology · 2026Article
- Experience-dependent modulation of collective behavior in larval zebrafish.Nature communications · 2026Article
- Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish.Science advances · 2026Article
- Dynamic trajectory cues drive sequenced integration in approach detectors.bioRxiv : the preprint server for biology · 2026Article
- Disruption ofiScience · 2026Article
- To jump or not to jump: comparing effects of phenotypic plasticity on the visual responses and escape behavior of locusts and grasshoppers.Journal of neurophysiology · 2026Article
- Article
- Interpeduncular GABAergic neuron function controls threat processing and innate defensive adaptive learning.Molecular psychiatry · 2025Article
- Attentional switching in larval zebrafish.Science advances · 2025Article
- On analogies in vertebrate and insect visual systems.Nature reviews. Neuroscience · 2025Review
- Article
- Review
- Surrogate GPR139 Agonists Reverse Short-Term Startle Habituation Impairment in Larval Zebrafish.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Brain-Wide Impacts of Sedation on Spontaneous Activity and Auditory Processing in Larval Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Habituation learning: insights from zebrafish larvae.Frontiers in molecular neuroscience · 2025Review
- Article
- Habituation as optimal filtering.iScience · 2024Article
- Light wavelength modulates search behavior performance in zebrafish.Scientific reports · 2024Article
- A Visual Interface for Exploring Hypotheses About Neural Circuits.IEEE transactions on visualization and computer graphics · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Larval zebrafish that are exposed repeatedly to dark looming stimuli will quickly habituate to these aversive signals and cease to respond with their stereotypical escape swims. A dark looming stimulus can be separated into two independent components: one that is characterized by an overall spatial expansion, where overall luminance is maintained at the same level, and a second, that represents an overall dimming within the whole visual field in the absence of any motion energy. Using specific stimulation patterns that isolate these independent components, we first extracted the behavioral algorithms that dictate how these separate information channels interact with each other and across the two eyes during the habituation process. Concurrent brain wide imaging experiments then permitted the construction of circuit models that suggest the existence of two separate neural pathways. The first is a looming channel which responds specifically to expanding edges presented to the contralateral eye and relays that information to the brain stem escape network to generate directed escapes. The second is a dimming-specific channel that could be either monocular or binocularly responsive, and that appears to specifically inhibit escape response when activated. We propose that this second channel is under strong contextual modulation and that it is primarily responsible for the incremental silencing of successive dark looming-evoked escapes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.