Evidence map›Paper›PMID 36916755›Full record

ArticleMedical physics2023

Simulation studies of a full-ring, CZT SPECT system for whole-body imaging of

Yoonsuk Huh, Javier Caravaca, Jaehyuk Kim, Yonggang Cui, Qiu Huang, Grant Gullberg, Youngho Seo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical physics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Individual and Simultaneous Imaging ofIEEE transactions on radiation and plasma medical sciences · 2025
    Article
  3. EANM perspectives for CZT SPECT in brain applications.European journal of nuclear medicine and molecular imaging · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Yoonsuk HuhDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Javier CaravacaDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Jaehyuk KimPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Yonggang CuiDepartment of Nonproliferation and National Security, Brookhaven National Laboratory, Upton, New York, USA.
Qiu HuangSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Grant GullbergDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Youngho SeoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
University of California, San Francisco · USBrookhaven National Laboratory · USQB3 · USShanghai Jiao Tong University · CNUniversity Health Network · CA

Funding

A high sensitivity gamma camera using a combination of Compton reconstruction and source proximity for in-vivo imaging of Ac-225R01EB032324 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CARAVACA, JAVIER · 2022 to 2025
$3.7M
Energy-independent single photon molecular imaging technologyR01EB026331 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CUI, YONGGANG, SEO, YOUNGHO · 2018 to 2022
$2.6M
Dynamic cardiac SPECTR01HL135490 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GULLBERG, GRANT T, SEO, YOUNGHO · 2017 to 2020
$2.4M
Energy-Independent Single Photon Molecular Imaging TechnologyR01EB012965 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CUI, YONGGANG, SEO, YOUNGHO · 2011 to 2014
$2.2M
NHLBI NIH HHS R01 HL135490NHLBI NIH HHS R01HL135490NIBIB NIH HHS R01 EB012965NIBIB NIH HHS R01EB012965NIBIB NIH HHS R01 EB026331NIBIB NIH HHS R01EB026331NIBIB NIH HHS R01 EB032324
6 · The paper itself

Abstract

backgroundSingle photon emission computed tomography (SPECT) is an imaging modality that has demonstrated its utility in a number of clinical indications. Despite this progress, a high sensitivity, high spatial resolution, multi-tracer SPECT with a large field of view suitable for whole-body imaging of a broad range of radiotracers for theranostics is not available. PURPOSE: With the goal of filling this technological gap, we have designed a cadmium zinc telluride (CZT) full-ring SPECT scanner instrumented with a broad-energy tungsten collimator. The final purpose is to provide a multi-tracer solution for brain and whole-body imaging. Our static SPECT does not rely on the dual- and the triple-head rotational SPECT standard paradigm, enabling a larger effective area in each scan to increase the sensitivity. We provide a demonstration of the performance of our design using a realistic model of our detector with simulated body-sized phantoms filled with

methodsWe create a realistic model of our detector by using a combination of a Geant4 Application for Tomographic Emission (GATE) Monte Carlo simulation and a finite element model for the CZT response, accounting for low-energy tail effects in CZT that affects the sensitivity and the scatter correction. We implement a modified dual-energy-window scatter correction adapted for CZT. Other corrections for attenuation, detector and collimator response, and detector gaps and edges are also included. The images are reconstructed using the maximum-likelihood expectation-maximization. Detector and reconstruction performance are characterized with point sources, Derenzo phantoms, and a body-sized National Electrical Manufacturers Association (NEMA) Image Quality (IQ) phantom for both

resultsOur SPECT design can resolve 7.9 mm rods for

conclusionsIn this paper, we demonstrate the good performance of our design for whole-body imaging purposes. This adds to our previous demonstration of improved qualitative and quantitative

Indexed as

CadmiumWhole Body ImagingIodine RadioisotopesPhantoms, ImagingTelluriumTomography, Emission-Computed, Single-PhotonZincCadmiumCdZnTeIodine-123Iodine RadioisotopesTelluriumZincCZTfinite element methodfull-ringMonte Carlo simulationSPECT

Identifiers

PMID36916755
PMCPMC10503418
OpenAlexW4324128674

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.