ArticleJournal of clinical laboratory analysis2023
Significant elevations of serum amylase caused by macroamylase: Case reports and detection possibilities.
Article in Journal of clinical laboratory analysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 8 citations in OpenAlex.
- Serum and Salivary Amylase Variations During Exercise Testing in Athletes and Their Correlation with Cardiovascular Parameters-A Pilot Study.Medicina (Kaunas, Lithuania) · 2026Article
- B-Cell Chronic Lymphocytic Leukemia in a Cat.Veterinary clinical pathology · 2025Article
- Macroamylasemia versus Hyperamylasemia.Korean journal of family medicine · 2024Article
- Significant elevations of serum amylase caused by macroamylase: Case reports and detection possibilities.Journal of clinical laboratory analysis · 2023Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe presence of isolated elevated serum amylase levels can be caused by high molecular mass complexes. We describe 13 cases of hyperamylasemia detected in adult patients without clinical symptoms of a pancreatic disorder. Five of them were thoroughly examined using different tools for the detection of macrocomplexes.
methodsWe performed both screening and more advanced methods of macroamylase detection, including polyethylene glycol precipitation, sample storage at 4°C and separation by gel filtration.
resultsThe presence of macroamylase in the suspected samples was confirmed by the methods described, except for the sample storage at 4°C. In this method, the enzyme activity did not decrease. The polyethylene glycol precipitation activity (% PPA) averaged 89.1% for amylase, whereas the control samples averaged 30.7%. Gel filtration chromatography confirmed an IgA macroamylase peak in three samples and an IgG macroamylase peak in two samples.
conclusionThe presence of macroamylase should be suspected whenever the clinical history and condition of the patient do not match the measured enzyme value to avoid diagnostic errors and unnecessary invasive examinations. The presence of macrocomplexes is considered a benign process that may occur in apparently healthy individuals. Cooperation between clinicians and laboratory staff is necessary.
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