ArticleJournal of the American Medical Informatics Association : JAMIA2023
Blockchain-enabled immutable, distributed, and highly available clinical research activity logging system for federated COVID-19 data analysis from multiple institutions.
Article in Journal of the American Medical Informatics Association : JAMIA, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Smart Contracts and Shared Platforms in Sustainable Health Care: Systematic Review.JMIR medical informatics · 2025Pooled it
- Biomedical blockchain with practical implementations and quantitative evaluations: a systematic review.Journal of the American Medical Informatics Association : JAMIA · 2024Pooled it
- Distributed cross-learning for equitable federated models - privacy-preserving prediction on data from five California hospitals.Nature communications · 2025Article
- Distributed, immutable, and transparent biomedical limited data set request management on multi-capacity network.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- A framework for sharing of clinical and genetic data for precision medicine applications.Nature medicine · 2024Article
- Distributed management of patient data-sharing informed consents for clinical research.Computers in biology and medicine · 2024Article
- WebQuorumChain: A web framework for quorum-based health care model learning.Informatics in medicine unlocked · 2024Article
- Promoting TEFCA with Blockchain Technology: A Decentralized Approach to Patient-centered Healthcare Data Management.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2023Article
- Variations in Electronic Health Record-Based Definitions of Diabetic Retinopathy Cohorts: A Literature Review and Quantitative Analysis.Ophthalmology scienceArticle
- Federated Learning in Glaucoma: A Comprehensive Review and Future Perspectives.Ophthalmology. GlaucomaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveWe aimed to develop a distributed, immutable, and highly available cross-cloud blockchain system to facilitate federated data analysis activities among multiple institutions. MATERIALS AND
methodsWe preprocessed 9166 COVID-19 Structured Query Language (SQL) code, summary statistics, and user activity logs, from the GitHub repository of the Reliable Response Data Discovery for COVID-19 (R2D2) Consortium. The repository collected local summary statistics from participating institutions and aggregated the global result to a COVID-19-related clinical query, previously posted by clinicians on a website. We developed both on-chain and off-chain components to store/query these activity logs and their associated queries/results on a blockchain for immutability, transparency, and high availability of research communication. We measured run-time efficiency of contract deployment, network transactions, and confirmed the accuracy of recorded logs compared to a centralized baseline solution.
resultsThe smart contract deployment took 4.5 s on an average. The time to record an activity log on blockchain was slightly over 2 s, versus 5-9 s for baseline. For querying, each query took on an average less than 0.4 s on blockchain, versus around 2.1 s for baseline. DISCUSSION: The low deployment, recording, and querying times confirm the feasibility of our cross-cloud, blockchain-based federated data analysis system. We have yet to evaluate the system on a larger network with multiple nodes per cloud, to consider how to accommodate a surge in activities, and to investigate methods to lower querying time as the blockchain grows.
conclusionBlockchain technology can be used to support federated data analysis among multiple institutions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.