Evidence map›Paper›PMID 36916205›Full record

ArticleThe Journal of physiology2023

Facilitation of sensory transmission to motoneurons during cortical or sensory-evoked primary afferent depolarization (PAD) in humans.

Krista Metz, Isabel Concha Matos, Yaqing Li, Babak Afsharipour, Christopher K Thompson, Francesco Negro, Katharina A Quinlan, David J Bennett, Monica A Gorassini

Open access · hybridAbstract read
In one paragraph

Article in The Journal of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Recovery of Dexterous Motor Control via Non-Monosynaptic Corticospinal Pathways.medRxiv : the preprint server for health sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Krista MetzBiomedical Engineering, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.ORCID 0000-0003-4223-7391
Isabel Concha MatosBiomedical Engineering, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Yaqing LiFaculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada.
Babak AfsharipourBiomedical Engineering, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Christopher K ThompsonHealth and Rehabilitation Sciences, Temple University, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-4920-4023
Francesco NegroClinical and Experimental Sciences, Universita degli Studi di Brescia, Brescia, Italy.ORCID 0000-0002-9094-8932
Katharina A QuinlanGeorge and Anne Ryan Institute for Neuroscience, Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, USA.ORCID 0000-0002-6177-4849
David J BennettFaculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada.
Monica A GorassiniBiomedical Engineering, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.ORCID 0000-0003-3079-6129
University of Alberta · CATemple University Hospital · USUniversity of Brescia · ITUniversity of Rhode Island · US

Funding

Impairment of Spinal Development in Cerebral PalsyR01NS104436 · NINDS · UNIVERSITY OF RHODE ISLAND · PI Katharina Ann Quinlan · 2017 to 2026
$4.3M
Recovery of motoneuron excitability after spinal injuryR01NS048170 · NINDS · UNIVERSITY OF ALBERTA · PI GORASSINI, MONICA A · 2006 to 2010
$1.0M
NINDS NIH HHS R01 NS048170NINDS NIH HHS R01 NS104436
6 · The paper itself

Abstract

Sensory and corticospinal tract (CST) pathways activate spinal GABAergic interneurons that have axoaxonic connections onto proprioceptive (Ia) afferents that cause long-lasting depolarizations (termed primary afferent depolarization, PAD). In rodents, sensory-evoked PAD is produced by GABA

Indexed as

Motor NeuronsSpinal CordAfferent Pathwaysgamma-Aminobutyric AcidHumansMuscle, SkeletalNeurons, AfferentPyramidal TractsSynaptic Transmissiongamma-Aminobutyric AcidH-reflexpresynaptic inhibitionproprioceptive afferents

Identifiers

PMID36916205
PMCPMC11037101
OpenAlexW4324128794

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.