Evidence map›Paper›PMID 36915910›Full record

ArticleJournal of virus eradication2023

Adeno-associated virus-vectored delivery of HIV biologics: the promise of a "single-shot" functional cure for HIV infection.

Patricia A Hahn, Mauricio A Martins

Open access · goldAbstract read
In one paragraph

Article in Journal of virus eradication, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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  9. Article
  10. Advances in HIV Gene Therapy.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Patricia A HahnDepartment of Immunology and Microbiology, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, 33458, USA.
Mauricio A MartinsDepartment of Immunology and Microbiology, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, 33458, USA.
Scripps Research Institute · USThe Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology

Funding

University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Savita Pahwa · 2007 to 2026
$33.8M
Project 4: A permanent off-switch for AAVU19AI149646 · NIAID · UNIVERSITY OF FLORIDA · PI FARZAN, MICHAEL R. · 2020 to 2024
$14.0M
AAV-mediated delivery of eCD4-Ig for prevention and treatment of perinatal HIV infectionR01HD102252 · NICHD · UNIVERSITY OF FLORIDA · PI MARTINS, MAURICIO DE AGUIAR · 2020 to 2024
$4.1M
eCD4-Ig for preventing and treating obstetric HIV infectionR01HD103494 · NICHD · UNIVERSITY OF FLORIDA · PI MARTINS, MAURICIO DE AGUIAR · 2020 to 2024
$4.0M
Overcoming pre-existing immunity to AAV to enhance AAV-based HIV immunotherapiesR01AI175007 · NIAID · UNIVERSITY OF FLORIDA · PI Mauricio A Martins · 2023 to 2026
$3.5M
A nonhuman primate model to study the immunological effects of feminizing hormone therapy in transgender womenR21AI157929 · NIAID · UNIVERSITY OF FLORIDA · PI MARTINS, MAURICIO DE AGUIAR · 2021 to 2022
$477k
NIAID NIH HHS P30 AI073961NIAID NIH HHS R01 AI175007NIAID NIH HHS R21 AI157929NIAID NIH HHS U19 AI149646NICHD NIH HHS R01 HD102252NICHD NIH HHS R01 HD103494
6 · The paper itself

Abstract

The ability of immunoglobulin-based HIV biologics (Ig-HIV), including broadly neutralizing antibodies, to suppress viral replication in pre-clinical and clinical studies illustrates how these molecules can serve as alternatives or adjuncts to antiretroviral therapy for treating HIV infection. However, the current paradigm for delivering Ig-HIVs requires repeated passive infusions, which faces both logistical and economic challenges to broad-scale implementation. One promising way to overcome these obstacles and achieve sustained expression of Ig-HIVs

Identifiers

PMID36915910
PMCPMC10005911
OpenAlexW4321189918

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.