Evidence map›Paper›PMID 36915836›Full record

ArticleCureus2023

Rituximab-Induced Immune Dysregulation Leading to Organizing Pneumonia, Bronchiectasis, and Pulmonary Fibrosis.

Mohammed Ayyad, Jehad Azar, Maram Albandak, Haneen Sharabati, Hamza Salim, Yasmin Jaber, Mohammed Al-Tawil

Open access · diamondFull text readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Secondary Immunodeficiency and Non-cystic Fibrosis Bronchiectasis.Tuberculosis and respiratory diseases · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Mohammed AyyadInternal Medicine, Al-Quds University, Jerusalem, PSE.
Jehad AzarRespiratory Institute, Cleveland Clinic, Cleveland, USA.
Maram AlbandakInternal Medicine, Al-Quds University, Jerusalem, PSE.
Haneen SharabatiInternal Medicine, Al-Quds University, Jerusalem, PSE.
Hamza SalimDepartment of Medicine, An-Najah National University, Nablus, PSE.
Yasmin JaberInternal Medicine B, Hadassah Ein Kerem Hospital, Jerusalem, ISR.
Mohammed Al-TawilInternal Medicine, Al-Quds University, Jerusalem, PSE.
An-Najah National University · PSHadassah Medical Center · ILCleveland Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a case of rituximab-induced organizing pneumonia (OP) along with bronchiectasis and pulmonary fibrosis, in a patient with a history of granulomatosis with polyangiitis (GPA), on long-term maintenance therapy with rituximab. T-cell dysregulation and B-cell depletion associated with the chronic use of rituximab often lead to a profound immunosuppressed state with hypogammaglobulinemia and unbalanced T-cell response. This acquired immunodeficient state with severe immune dysregulation predisposed this patient to recurrent pulmonary infection and ultimately led to bronchiectasis and pulmonary fibrosis.

Indexed as

bronchiectasisgranulomatosis with polyangiitishumoral immunityhypogammaglobulinemiaimmunosuppression therapypulmonary fibrosisrituximab

Identifiers

PMID36915836
PMCPMC10007905
OpenAlexW4319736086

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read3
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.