Evidence map›Paper›PMID 36915790›Full record

ArticleAmerican journal of translational research2023

A novel GJA5 variant associated with increased risk of essential hypertension.

Juan Wang, Xue-Cheng Wang, Zhao-Hua Gu, Guang-Wei Ren, Xiao-Hong Zhao, Xin-Kai Qu, Ying-Jia Xu, Yi-Qing Yang

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Discovery and functional investigation ofAmerican journal of translational research · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Juan WangDepartment of Cardiovascular Medicine, East Hospital, Tongji University School of Medicine Shanghai 200120, China.
Xue-Cheng WangDepartment of Cardiovascular Medicine, East Hospital, Tongji University School of Medicine Shanghai 200120, China.
Zhao-Hua GuSanlin Community Health Service Center Pudong New District, Shanghai 200124, China.
Guang-Wei RenSanlin Community Health Service Center Pudong New District, Shanghai 200124, China.
Xiao-Hong ZhaoDepartment of Cardiovascular Medicine, East Hospital, Tongji University School of Medicine Shanghai 200120, China.
Xin-Kai QuDepartment of Cardiology, Huadong Hospital, Fudan University Shanghai 200040, China.
Ying-Jia XuDepartment of Cardiology, Shanghai Fifth People's Hospital, Fudan University Shanghai 200240, China.
Yi-Qing YangDepartment of Cardiology, Shanghai Fifth People's Hospital, Fudan University Shanghai 200240, China.
Shanghai East Hospital · CNCommunity Health Center · USFudan University · CNHuadong Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesGap junction protein alpha 5 (GJA5), also termed connexin 40 (Cx40), exerts a pivotal role in the mediation of vascular wall tone and two closely-linked polymorphisms in the

methodsFor this investigation, 380 unrelated patients with EH and 396 unrelated normotensive individuals employed as control persons were enrolled from the Chinese Han-ethnicity population, and their

resultsThe

conclusionsThese findings indicate that the novel variant upstream of the

Indexed as

Essential hypertensiongap junction proteinGJA5molecular geneticsreninreporter gene assay

Identifiers

PMID36915790
PMCPMC10006783
OpenAlexW4324130185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.