ArticleAmerican journal of translational research2023
Microstructural changes of cartilage and subchondral bone in a guinea pig model of early- and middle-stage patellofemoral arthritis.
Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 1 citations in OpenAlex.
- Establishment and validation of a novel rat model of early-stage patellofemoral osteoarthritis induced by patellar instability.Frontiers in surgery · 2026Article
- Difference in quantitative MRI measurements of cartilage between Wiberg type III patella and stable patella based on a 3.0-T synthetic MRI sequence.European journal of radiology open · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePatellofemoral arthritis is a common type of knee osteoarthritis and a prime cause of anterior knee pain and disability. Most of the existing research on knee osteoarthritis focuses on tibial-femoral arthritis, while studies on patellofemoral arthritis are relatively rare. This study aims to observe changes in osteochondral and subchondral bone structure over time in the patella and femoral trochlea in an animal model of spontaneous patellofemoral arthritis.
methodsA total of 24 1-, 3- or 5-month-old healthy female Hartley guinea pigs were used for experiments. No intervention was applied, and the mechanical pain threshold was assessed prior to euthanasia. Bilateral knee joints were collected in the animals at the different ages, and the patellofemoral joints were taken to evaluate the bone microstructure of patellofemoral articular cartilage and subchondral bone by macroscopy, histopathology and micro-computed tomography (micro-CT).
resultsThere was a significant difference in the severity of femoral trochlea injury assessed by the Macro score between 5- and 1-month-old groups (P<0.01), as well as in patellar cartilage damage (P<0.05). The mechanical pain threshold of lower extremities in each group was statistically different between different age groups (P<0.05). The OARSI articular cartilage histopathological scores, including patella and femoral trochlea, were significantly different among 1-, 3- and 5-month-old groups. The 5-month-old group exhibited statistically lower values of bone volume/trabecular volume, trabecular number and trabecular thickness in the femoral subchondral bone and evidently higher structure model index than the 1-month-old group.
conclusionsThis study demonstrated that 3- to 5-month-old female Hartley guinea pigs can develop early-to-mid-stage spontaneous patellofemoral arthritis that causes significant cartilage degeneration and loss of subchondral bone. In addition, the bone microarchitecture of the femur is more severely degraded.
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Identifiers
36915787PMC10006769W4324129870What OpenQuestion holds
Registered trials
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