Protective effect and mechanism of γ-secretase inhibitor on myocardial injury in sepsis rats.

Jingyun Fang, Yuming Zhou

Open access · greenAbstract read

In one paragraph

Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 98% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jingyun FangDepartment of Emergency, Ganzhou People's Hospital Ganzhou 341000, Jiangxi, China.

Yuming ZhouDepartment of Emergency, Ganzhou People's Hospital Ganzhou 341000, Jiangxi, China.

Ganzhou People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to investigate the mechanism of γ-secretase inhibitor (GSI) in myocardial repair in septic rats.

methodsThirty-six healthy male Wistar rats were randomly and equally divided into control groups, model group and intervention group. The model group and the intervention group were treated with ligation of cecum and perforation to build sepsis model, and the intervention group received intraperitoneal injection of GSI II (DAPT). Serum levels of Troponin T (cTnT), creatine kinase isoenzyme (CK-MB) and interleukin-17 were measured by ELISA. The Th17 cell percentage in peripheral blood mononuclear cells in CD4

resultsThe cTnT, CK-MB, Th17 and Th17/CD4

conclusionγ secretase inhibitors have clearly protective effects on cardiomyocytes, and the mechanism may be associated with Notch blocking and RORγt expression, which inhibit immune damage induced by abnormal activation of Th17.

Indexed as

mechanismmyocardial injurymyocardial protectionsepsisγ secretase inhibitor

Identifiers

PMID36915749

PMCPMC10006822

OpenAlexW4324128816

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.