Evidence map›Paper›PMID 36915710›Full record

ReviewAmerican journal of preventive cardiology2023

Call to action: Understanding the differences in the use of SGLT-2 inhibitors and GLP-1 receptor agonists.

Apurva Khedagi, Cara Hoke, Michelle Kelsey, Andrea Coviello, W Schuyler Jones, Larry R Jackson, Manesh R Patel, Rob W McGarrah, Neha J Pagidipati, Nishant P Shah

Open access · goldAbstract readReview
In one paragraph

Review in American journal of preventive cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Apurva KhedagiDepartment of Medicine, Duke University School of Medicine, Durham, NC.
Cara HokeDivision of Cardiology, Duke University School of Medicine, Durham, NC.
Michelle KelseyDivision of Cardiology, Duke University School of Medicine, Durham, NC.
Andrea CovielloDivision of Endocrinology, Metabolism, and Nutrition, Duke University School of Medicine.
W Schuyler JonesDivision of Cardiology, Duke University School of Medicine, Durham, NC.
Larry R JacksonDivision of Cardiology, Duke University School of Medicine, Durham, NC.
Manesh R PatelDivision of Cardiology, Duke University School of Medicine, Durham, NC.
Rob W McGarrahDivision of Cardiology, Duke University School of Medicine, Durham, NC.
Neha J PagidipatiDivision of Cardiology, Duke University School of Medicine, Durham, NC.
Nishant P ShahDivision of Cardiology, Duke University School of Medicine, Durham, NC.
Duke University · US

Funding

Shared Decision-Making to Reduce Racial Disparities in Oral Anticoagulation Use in Patients with Non-Valvular Atrial FibrillationK01HL159041 · NHLBI · DUKE UNIVERSITY · PI JACKSON, LARRY R · 2021 to 2025
$774k
6 · The paper itself

Abstract

Cardiovascular disease remains one of the most prominent global health problems and has been demonstrated to disproportionally affect certain communities. Despite an increasing collective effort to improve health inequalities, a multitude of disparities continue to affect cardiovascular outcomes. Among the most prominent disparities within cardiovascular disease prevention are with the use and distribution of sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like peptide 1 (GLP-1) receptor agonists. Several landmark trials have demonstrated the efficacy of these novel agents, not only in cardiovascular disease prevention among those with diabetes, but also in heart failure and chronic kidney disease. However, the use of these agents remains limited by disparities in certain racial/ethnic, sex, and socioeconomic groups. This review works to highlight and understand these differences on the use and prescribing patterns of pivotal agents in cardiovascular disease prevention, SGLT-2 inhibitors and GLP-1 agonists. Our aim is to enrich understanding and to inspire efforts to end disparities in cardiovascular morbidity and mortality due to race, sex and income inequality.

Indexed as

DisparitiesGLP1-RAHealth equityPreventionSGLT2i

Identifiers

PMID36915710
PMCPMC10006446
OpenAlexW4321793105

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.