Evidence map›Paper›PMID 36915611›Full record

ArticleNeuro-oncology advances

CDKN2A/B co-deletion is associated with increased risk of local and distant intracranial recurrence after surgical resection of brain metastases.

Ramin A Morshed, Minh P Nguyen, Daniel D Cummins, Satvir Saggi, Jacob S Young, Alexander F Haddad, Ezequiel Goldschmidt, Edward F Chang, Michael W McDermott, Mitchel S Berger and 4 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Ramin A MorshedDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Minh P NguyenDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Daniel D CumminsDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Satvir SaggiDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Jacob S YoungDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-5499-4325
Alexander F HaddadDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Ezequiel GoldschmidtDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Edward F ChangDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Michael W McDermottDivision of Neurosurgery, Miami Neuroscience Institute, Miami, FL, USA.ORCID https://orcid.org/0000-0002-7635-5268
Mitchel S BergerDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Philip V TheodosopoulosDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Shawn L Hervey-JumperDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Mariza DarasDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Manish K AghiDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
University of California, San Francisco · US

Funding

Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
Modeling and druggable-genome screening of glioblastoma invasion using regional biopsy-guided biomaterials systemsR01CA227136 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AGHI, MANISH · 2018 to 2022
$2.2M
NCI NIH HHS R01 CA227136NCI NIH HHS T32 CA151022
6 · The paper itself

Abstract

Background: While genetic alterations in brain metastases (BMs) have been previously explored, there are limited data examining their association with recurrence after surgical resection. This study aimed to identify genetic alterations within BMs associated with CNS recurrence after surgery across multiple cancer types. Methods: A retrospective, single-center study was conducted with patients who underwent resection of a BM with available clinical and gene sequencing data available. Local and remote CNS recurrence were the primary study outcomes. Next-generation sequencing of the coding regions in over 500 oncogenes was performed in brain metastasis specimens. Cox proportional hazards analyses were performed to identify clinical features and genomic alterations associated with CNS recurrence. Results: A total of 90 patients undergoing resection of 91 BMs composed the cohort. Genes most frequently mutated in the cohort included Conclusions:

Indexed as

brain metastasisCDKN2ACDKN2Bdistant recurrencelocal recurrencesurgery

Identifiers

PMID36915611
PMCPMC10007908
OpenAlexW4318478500

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read186
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.