ArticleQuantitative imaging in medicine and surgery2023
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) quantification of transient ischemia using a combination method of 5-pool Lorentzian fitting and inverse Z-spectrum analysis.
Article in Quantitative imaging in medicine and surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 9 citations in OpenAlex.
- Amide proton transfer-weighted magnetic resonance imaging for the diagnosis of triple-negative breast cancer: a comparative study with diffusion-weighted imaging and dynamic contrast-enhanced magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2026Article
- CEST-MRI assessment of locally advanced pMMR rectal cancer for prediction of immune activation status following radiotherapy.European radiology · 2026Article
- Limited Contribution of TMolecular imaging and biology · 2026Article
- CEST MRI: Translational prospects for intervertebral disc degeneration - from basic research to clinical applications.Journal of orthopaedic translation · 2026Review
- CEST MRI Processing Pipeline in Pilot Study of Alzheimer's Disease Patients.Magnetic resonance in medicine · 2026Article
- Chemical exchange saturation transfer imaging and diffusion weighted imaging for colon 26 tumor bearing mice.Scientific reports · 2025Article
- Multiparametric Chemical Exchange Saturation Transfer MRI Detects Metabolic Changes in Mild Cognitive Impairment Cases at 3.0 Tesla.Neurochemical research · 2024Article
- Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges.International journal of molecular sciences · 2024Review
- Noninvasive Characterization of Metabolic Changes in Ischemic Stroke Using Z-spectrum-fitted Multiparametric Chemical Exchange Saturation Transfer-weighted Magnetic Resonance Imaging.Current medical science · 2023Article
- Quantitative assessment of cardiac phosphocreatine metabolism under physiological and pharmacological stress using chemical exchange saturation transfer magnetic resonance imaging.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceArticle
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7 authors at 3 institutions in 1 country.
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Abstract
Background: Chemical exchange saturation transfer (CEST) is a promising method for the detection of biochemical alterations in cancers and neurological diseases. However, the sensitivity of the currently existing quantitative method for detecting ischemia needs further improvement. Methods: To further improve the quantification of the CEST signal and enhance the CEST detection for ischemia, we used a quantitative analysis method that combines an inverse Z-spectrum analysis and a 5-pool Lorentzian fitting. Specifically, a 5-pool Lorentzian simulation was conducted with the following brain tissue parameters: water, amide (3.5 ppm), amine (2.2 ppm), magnetization transfer (MT), and nuclear Overhauser enhancement (NOE; -3.5 ppm). The parameters were first calculated offline and stored as the initial value of the Z-spectrum fitting. Then, the measured Z-spectrum with the peak value set to 0 was fitted via the stored initial value, which yielded the reference Z-spectrum. Finally, the difference between the inverse of the Z-spectrum and the inverse of the reference Z-spectrum was used as the CEST definite spectrum. Results: The simulation results demonstrated that the Z-spectra of the rat brain were well simulated by a 5-pool Lorentzian fitting. Further, the proposed method detected a larger difference than did either the saturation transfer difference or the 5-pool Lorentzian fitting, as demonstrated by simulations. According to the results of the cerebral ischemia rat model, the proposed method provided the highest contrast-to-noise ratio (CNR) between the contralateral and the ipsilateral striatum under various acquisition conditions. The results indicated that the difference of fitted amplitudes generated with a 5-pool Lorentzian fitting in amide at 3.5 ppm (6.04%±0.39%; 6.86%±0.39%) was decreased in a stroke lesion compared to the contralateral normal tissue. Moreover, the difference of the residual of inversed Z-spectra in which 5-pool Lorentzian fitting was used to calculate the reference Z-spectra ( Conclusions:
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