Evidence map›Paper›PMID 36915236›Full record

ArticleActa obstetricia et gynecologica Scandinavica2024

Pregnancy-associated gynecological cancer in New South Wales, Australia 1994-2013: A population-based historical cohort study.

Penelope Fotheringham, Nadom Safi, Zhouyang Li, Antoinette Anazodo, Marc Remond, Andrew Hayen, David Currow, David Roder, Nada Hamad, Michael Nicholl and 3 more

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In one paragraph

Article in Acta obstetricia et gynecologica Scandinavica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. The challenges of cancer during pregnancy.Acta obstetricia et gynecologica Scandinavica · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Penelope FotheringhamCollege of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.ORCID 0000-0003-1853-8194
Nadom SafiCollege of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.ORCID 0000-0001-8473-0980
Zhouyang LiCollege of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.
Antoinette AnazodoNelune Comprehensive Cancer Centre, Prince of Wales Hospital, Randwick, New South Wales, Australia.
Marc RemondCollege of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.ORCID 0000-0001-7796-4447
Andrew HayenSchool of Public Health, University of Technology Sydney, Ultimo, New South Wales, Australia.
David CurrowFaculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, Australia.
David RoderPopulation Health, Beat Cancer Project, University of South Australia, Adelaide, South Australia, Australia.
Nada HamadThe Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.
Michael NichollFaculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
Adrienne GordonFaculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
Jane FrawleySchool of Public Health, University of Technology Sydney, Ultimo, New South Wales, Australia.
Elizabeth A SullivanCollege of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.

Funding

Cancer Council NSW reference RG 18-02
6 · The paper itself

Abstract

introductionPregnancy-associated gynecological cancer (PAGC) refers to cancers of the ovary, uterus, fallopian tube, cervix, vagina, and vulva diagnosed during pregnancy or within 12 months postpartum. We aimed to describe the incidence of, and perinatal outcomes associated with, invasive pregnancy-associated gynecological cancer. MATERIAL AND

methodsWe conducted a population-based historical cohort study using linked data from New South Wales, Australia. We included all women who gave birth between 1994 and 2013, with a follow-up period extending to September 30, 2018. Three groups were analyzed: a gestational PAGC group (women diagnosed during pregnancy), a postpartum PAGC group (women diagnosed within 1 year of giving birth), and a control group (women with control diagnosis during pregnancy or within 1 year of giving birth). We used generalized estimation equations to compare perinatal outcomes between study groups.

resultsThere were 1 786 137 deliveries during the study period; 70 women were diagnosed with gestational PAGC and 191 with postpartum PAGC. The incidence of PAGC was 14.6/100 000 deliveries and did not change during the study period. Women with gestational PAGC (adjusted odds ratio [aAOR] 6.81, 95% confidence interval [CI] 2.97-15.62) and with postpartum PAGC (aOR 2.65, 95% CI 1.25-5.61) had significantly increased odds of a severe maternal morbidity outcome compared with the control group. Babies born to women with gestational PAGC were more likely to be born preterm (aOR 3.11, 95% CI 1.47-6.59) and were at increased odds of severe neonatal complications (aOR 3.47, 95% CI 1.45-8.31) compared with babies born to women without PAC.

conclusionsThe incidence of PAGC has not increased over time perhaps reflecting, in part, the effectiveness of cervical screening and early impacts of human papillomavirus vaccination programs in Australia. The higher rate of preterm birth among the gestational PAGC group is associated with adverse outcomes in babies born to these women.

Indexed as

Papillomavirus InfectionsPapillomavirus VaccinesPremature BirthUterine Cervical NeoplasmsAustraliaCohort StudiesEarly Detection of CancerFemaleHumansInfant, NewbornNew South WalesParturitionPregnancyPregnancy OutcomePapillomavirus Vaccinescancer in pregnancygynecological canceriatrogenic prematuritymaternal outcomeneonatal outcomeperinatal outcome

Identifiers

PMID36915236
PMCPMC10993344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.