Evidence map›Paper›PMID 36915059›Full record

Observational studyBMC ophthalmology2023

Effects of atropine and tropicamide on ocular biological parameters in children: a prospective observational study.

Yulin Tao, Mohan Li, Jian Tan, Jing Huang, Xiaokang Cheng, Ping Xie, Xiansheng Liu, Qiong Zhou, Jun Ouyang

Open access · goldFull text readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yulin Tao *Department of Ophthalmology, Jiujiang No 1 Peoples Hospital, Affiliated Jiujiang Hospital of Nanchang University, 48 South Taling Road, Jiujiang, 332000, Jiangxi, China.
Mohan Li *Department of Ophthalmology, The Second Hospital of Anhui Medical University, No.678 Furong Road, Economic Development Zone, Hefei, 230031, Anhui, China.
Jian Tan *Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Center of National Ocular Disease Clinical Research Center, 17 Yongwai Main Street, Nanchang, 330006, Jiangxi, China.
Jing HuangDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Center of National Ocular Disease Clinical Research Center, 17 Yongwai Main Street, Nanchang, 330006, Jiangxi, China.
Xiaokang ChengDepartment of Ophthalmology, Jiujiang No 1 Peoples Hospital, Affiliated Jiujiang Hospital of Nanchang University, 48 South Taling Road, Jiujiang, 332000, Jiangxi, China.
Ping XieDepartment of Ophthalmology, Jiujiang No 1 Peoples Hospital, Affiliated Jiujiang Hospital of Nanchang University, 48 South Taling Road, Jiujiang, 332000, Jiangxi, China.
Xiansheng LiuDepartment of Ophthalmology, Jiujiang No 1 Peoples Hospital, Affiliated Jiujiang Hospital of Nanchang University, 48 South Taling Road, Jiujiang, 332000, Jiangxi, China.
Qiong ZhouDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Center of National Ocular Disease Clinical Research Center, 17 Yongwai Main Street, Nanchang, 330006, Jiangxi, China. qiongzd06@126.com.
Jun OuyangDepartment of Ophthalmology, Jiujiang No 1 Peoples Hospital, Affiliated Jiujiang Hospital of Nanchang University, 48 South Taling Road, Jiujiang, 332000, Jiangxi, China. 504219135@qq.com.
Jiujiang University · CNFirst Affiliated Hospital of Nanchang University · CNNanchang University · CNSecond Affiliated Hospital of Anhui Medical University · CN

Funding

the General Project of the Key R & D Program of the Department of Science and Technology of Jiangxi Province 005062833097the Science and Technology Plan Project of the Health Commission of Jiangxi Province 202140286the Science and Technology Program of Administration of traditional Chinese Medicine of Jiangxi Province 2021A151
6 · The paper itself

Abstract

backgroundThe effectiveness of cycloplegia in delaying the progression of myopia and its application in refractive examination in children have been extensively studied, but there are still few studies on the effects of atropine/tropicamide on ocular biological parameters. Therefore, the purpose of this study was to explore the effects of atropine/tropicamide on children's ocular biological parameters in different age groups and the differences between them.

methodsThis was a prospective observational study in which all school children were examined for dioptres and ocular biological parameters in the outpatient clinic, and 1% atropine or tropicamide was used for treatment. After examination, we enrolled the patients grouped by age (age from 2 to 12 years treated by atropine, 55 cases; age from 2 to 10 years treated by tropicamide, 70 cases; age from 14 to 17 years treated by tropicamide, 70 cases). The ocular biological parameters of each patient before and after cycloplegia were measured, and the difference and its absolute value were calculated for statistical analysis using an independent-samples t test.

resultsWe compared the value and the absolute value of the differences in ocular biological parameters before and after cycloplegia in the same age group, and we found that the differences were not statistically significant (P > 0.05). There were significant differences in the corresponding values of AL, K1 and ACD among the different age groups (P < 0.05). Before cycloplegia, there were significant differences in AL, K, K1, K2 and ACD in different age groups (P < 0.05). However, the differences in AL, K, K1, K2 and ACD among different age groups disappeared after cycloplegia (P > 0.05).

conclusionsThis study demonstrated that atropine/tropicamide have different effects on cycloplegia in children of different ages. The effects of atropine/tropicamide on ocular biological parameters should be fully considered when evaluating the refractive state before refractive surgery or mydriasis optometry for children of different ages.

Indexed as

PresbyopiaTropicamideAdolescentAtropineChildChild, PreschoolCiliary BodyHumansMydriaticsRefraction, OcularAtropineMydriaticsTropicamideAtropineChildrenCycloplegiaOcular biometryTropicamide

Identifiers

PMID36915059
PMCPMC10010000
OpenAlexW4324129996

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read36
table measurements read8
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.