ArticleNature genetics2023
Preneoplastic stromal cells promote BRCA1-mediated breast tumorigenesis.
Open access · greenAbstract read
In one paragraph
Article in Nature genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
20.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 60 citations in OpenAlex.
- The dual immune landscape of homologous recombination-deficient tumors: mechanisms and therapeutic implications.Cancer metastasis reviews · 2026Review
- Systemic immune activation in hereditary cancer predisposition syndromes: a cross-sectional study.BMC medicine · 2026Article
- Mouse genetic mosaic model for basal-like breast cancer reveals disruption of basal-myoepithelial architecture at premalignancy.Research square · 2026Article
- Choline metabolism drives metastasis in BRCA1-deficient ovarian cancers by activating FAM3C.Nature communications · 2026Article
- Inferring gene-regulatory networks using epigenomic priors.iScience · 2026Article
- The Human Male Mammary Gland has Similar Epithelial Populations to Female but Distinct Composition and Transcriptional Properties.bioRxiv : the preprint server for biology · 2026Article
- Mutational profiles of spontaneous and radiation-related mammary carcinomas in a rat model of Brca1 haploinsufficiency.Scientific reports · 2026Article
- Precancerous microenvironment: A signalling perspective.Current opinion in cell biology · 2026Review
- Decoding the gut-adipose-ovary axis in polycystic ovary syndrome: from metabolic dysregulation to oncological risk modulation.Frontiers in microbiology · 2026Review
- The breakome of BRCA1 and BRCA2 pathway mutation carriers reveals early processes in breast oncogenesis.Cell death & disease · 2025Article
- Healthy BRCA1/2 mutation carriers exhibit a pre-CAF signature and altered epithelial marker expression in breast tissue.Scientific reports · 2025Article
- Defining breast epithelial cell types in the single-cell era.Developmental cell · 2025Review
- CD105Breast cancer research : BCR · 2025Article
- Article
- Epigenomic disorder and partial EMT impair luminal progenitor integrity in Brca1-associated breast tumorigenesis.Molecular cancer · 2025Article
- [The role of immunosurveillance and immunoediting in hereditary cancer predisposition syndromes].Magyar onkologia · 2025Review
- Thirty Years of BRCA1: Mechanistic Insights and Their Impact on Mutation Carriers.Cancer discovery · 2025Review
- Article
- Comprehensive single-cell atlas of colorectal neuroendocrine tumors with liver metastases: unraveling tumor microenvironment heterogeneity between primary lesions and metastases.Molecular cancer · 2025Article
- SwarmMAP: Swarm Learning for Decentralized Cell Type Annotation in Single Cell Sequencing Data.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
- Commented on by
Authors and funding
24 authors at 3 institutions in 2 countries.
Kevin Nee *Department of Biological Chemistry, University of California, Irvine, CA, USA.
Dennis Ma *Department of Biological Chemistry, University of California, Irvine, CA, USA.
Quy H NguyenDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Maren PeinDepartment of Biological Chemistry, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-7906-5960
Nicholas PervolarakisDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Jacob Insua-RodríguezDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Yanwen GongDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Grace HernandezDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Hamad AlshetaiwiDepartment of Biological Chemistry, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0003-3144-7377
Justice WilliamsDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Maha RaufDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Kushal Rajiv DaveDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Keerti BoyapatiDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Aliza HasnainDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Christian CalderonDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Anush MarkaryanDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Robert EdwardsDepartment of Pathology and Laboratory Medicine, University of California Irvine Medical Center, Orange, CA, USA.
Erin LinDepartment of Surgery, University of California Irvine Medical Center, Orange, CA, USA.
Ritesh ParajuliDepartment of Surgery, University of California Irvine Medical Center, Orange, CA, USA.
Peijie ZhouDepartment of Mathematics, University of California, Irvine, CA, USA.
Qing NieDepartment of Mathematics, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-8804-3368
Sundus ShalabiBeckman Research Institute at City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0002-8440-2474
Mark A LaBargeBeckman Research Institute at City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0003-2405-4719
Kai KessenbrockDepartment of Biological Chemistry, University of California, Irvine, CA, USA. kai.kessenbrock@uci.edu.ORCID http://orcid.org/0000-0003-0410-6104
University of California, Irvine · USUniversity of California, Irvine Medical Center · USCity of Hope · US
Funding
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9MCARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6MMEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1MMicroenvironmental regulation of breast tumorigenesisR01CA234496 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kai Kessenbrock · 2019 to 2026
$4.3MProteolytic regulation of Wnt signaling in breast cancer stem cellsR00CA181490 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KESSENBROCK, KAI · 2016 to 2018
$730kInvestigating the role of pericytes as regulators of breast tissue homeostasis and cancer.F30CA243419 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI NEE, KEVIN · 2019 to 2022
$151kDefining the Roles of Mitochondria in Breast Cancer MetastasisK99CA267160 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI MA, DENNIS · 2022 to 2022
$118kNCI NIH HHS F30 CA243419NCI NIH HHS K99 CA267160NCI NIH HHS P30 CA062203NCI NIH HHS R00 CA181490NCI NIH HHS R01 CA234496NCI NIH HHS T32 CA009054NIGMS NIH HHS T32 GM008620
Abstract
Women with germline BRCA1 mutations (BRCA1
Indexed as
Breast NeoplasmsMammary Glands, HumanBRCA1 ProteinCarcinogenesisCell Transformation, NeoplasticFemaleHumansMutationStromal CellsBRCA1 ProteinBRCA1 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.