ArticleScientific reports2023
The remineralization effect of GERM CLEAN on early human enamel caries lesions in vitro.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Optimization strategies for antimicrobial peptides in dental caries prevention and management: from emerging mechanisms of action to clinical translation.Frontiers in microbiology · 2026Review
- Mechanical properties of simulated dentin caries treated with metal cations and L-ascorbic acid 2-phosphate.Odontology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate the remineralization effect of GERM CLEAN, a novel antibacterial peptide, on early enamel caries. Thirty human enamel blocks from thirty teeth were randomly divided into three groups: double distilled water (DDW group), GERM CLEAN (GC group), and 1000 ppm fluoride (NaF group). Specimens were demineralized for 3 days (pH 4.6) followed by pH cycling twice daily for 14 days. For a pH cycle, specimens received corresponding treatments for 5 min, then were immersed in demineralizing solution for 1 h, received corresponding treatments again, and finally were immersed in remineralizing solution (pH 7.0) for approximately 11 h. Specimens were washed with DDW after each treatment. Microindentation tests, atomic force microscopy (AFM), and transverse micro-radiography (TMR) were conducted to analyze enamel blocks. GC demonstrated a lower percentage of surface microhardness recovery (SMHR%) (p < 0.0001), rougher surfaces (p < 0.0001), deeper lesion depth (p = 0.001), and more mineral loss (p = 0.001) than NaF, but showed higher SMHR% (p < 0.0001), smoother surfaces (p < 0.0001), shallower lesion depth (p = 0.049), and less mineral loss (p = 0.001) than DDW. As a result, GERM CLEAN has the potential to promote the remineralization of demineralized enamel.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.