Evidence map›Paper›PMID 36914689›Full record

ArticleScientific reports2023

Antibacterial efficacy of synthesized silver nanoparticles of Microbacterium proteolyticum LA2(R) and Streptomyces rochei LA2(O) against biofilm forming meningitis causing microbes.

Naushin Bano, Danish Iqbal, Ayoub Al Othaim, Mehnaz Kamal, Hind Muteb Albadrani, Naseh A Algehainy, Hadeel Alyenbaawi, Fayez Alghofaili, Mohammad Amir, Roohi

Open access · goldFull text read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Nanoflowers: Smart Molecules for Biofilm Management.Applied biochemistry and biotechnology · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Green synthesis of silver nanoparticles byFrontiers in microbiology · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Naushin BanoProtein Research Laboratory, Department of Bioengineering, Integral University, Lucknow, 226026, India.
Danish IqbalDepartment of Health Information Management, College of Applied Medical Sciences, Buraydah Private Colleges, Buraydah, 51418, Saudi Arabia.
Ayoub Al OthaimDepartment of Medical Laboratory Sciences, College of Applied Medical Science, Majmaah University, Al-Majmaah, 11952, Saudi Arabia. ay.alothaim@mu.edu.sa.
Mehnaz KamalDepartment of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.
Hind Muteb AlbadraniDepartment of Medical Laboratory Sciences, College of Applied Medical Science, Majmaah University, Al-Majmaah, 11952, Saudi Arabia.
Naseh A AlgehainyDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, 71491, Saudi Arabia.
Hadeel AlyenbaawiDepartment of Medical Laboratory Sciences, College of Applied Medical Science, Majmaah University, Al-Majmaah, 11952, Saudi Arabia.
Fayez AlghofailiDepartment of Medical Laboratory Sciences, College of Applied Medical Science, Majmaah University, Al-Majmaah, 11952, Saudi Arabia.
Mohammad AmirProtein Research Laboratory, Department of Bioengineering, Integral University, Lucknow, 226026, India.
RoohiProtein Research Laboratory, Department of Bioengineering, Integral University, Lucknow, 226026, India. roohi0607@gmail.com.ORCID 0000-0003-4296-6105
Majmaah University · SAIntegral University · INBuraydah Colleges · SAPrince Sattam Bin Abdulaziz University · SAUniversity of Tabuk · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Actinobacteria obtained from the least explored Indian regions were studied for their ability to suppress meningitis-causing bacteria in nanoparticle form. Drug-resistant bacteria and long-term treatment with different medications make meningitis control complicated. Thus, new meningitis drugs are required to combat MDR bacteria. In this study, secondary metabolites isolated from actinomycetes strains, Microbacterium proteolyticum LA2(R) and Streptomyces rochei LA2(O), were employed to synthesize silver nanoparticles (AgNPs) at 37 °C for seven days incubation. UV-Vis spectroscopy, TEM, FTIR, and HPLC studies were used for the confirmation of the synthesis of AgNPs. Furthermore, these NPs demonstrated antibacterial and antibiofilm activities against meningitis-causing bacteria. The average size of LA2(R) and LA2(O) isolated secondary metabolites mediated AgNPs was observed to be 27 ± 1and 29 ± 2 nm by TEM analysis. FTIR study of RAgNPs and OAgNPs revealed that presence of peaks with positions of 1637.17 cm

Indexed as

ActinobacteriaActinomycetalesMeningitisMetal NanoparticlesStreptomycesAnti-Bacterial AgentsBiofilmsHumansMicrobacteriumMicrobial Sensitivity TestsSilverAnti-Bacterial AgentsSilver

Identifiers

PMID36914689
PMCPMC10011373
OpenAlexW4324055502

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read5
measurements read59
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.