Evidence map›Paper›PMID 36914431›Full record

ReviewTrends in biotechnology2023

Repurposing biomedical muscle tissue engineering for cellular agriculture: challenges and opportunities.

Mohamadmahdi Samandari, Farnoosh Saeedinejad, Jacob Quint, Sharon Xin Ying Chuah, Razieh Farzad, Ali Tamayol

Open access · greenAbstract readReview
In one paragraph

Review in Trends in biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mohamadmahdi SamandariDepartment of Biomedical Engineering, University of Connecticut, Farmington, CT, USA. Electronic address: samandari@uchc.edu.
Farnoosh SaeedinejadDepartment of Biomedical Engineering, University of Connecticut, Farmington, CT, USA.
Jacob QuintDepartment of Biomedical Engineering, University of Connecticut, Farmington, CT, USA.
Sharon Xin Ying ChuahFood Science and Human Nutrition Department, Florida Sea Grant and Global Food Systems Institute, University of Florida, Gainesville, FL, USA.
Razieh FarzadFood Science and Human Nutrition Department, Florida Sea Grant and Global Food Systems Institute, University of Florida, Gainesville, FL, USA. Electronic address: rfarzad@ufl.edu.
Ali TamayolDepartment of Biomedical Engineering, University of Connecticut, Farmington, CT, USA. Electronic address: atamayol@uchc.edu.
University of Connecticut · USUniversity of Florida · US

Funding

Suturable bioprinted vascularized muscle constructs for treatment of skeletal muscle lossR01AR077132 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SHIN, SU RYON, TAMAYOL, ALI · 2021 to 2025
$2.6M
Microengineered scaffolds carrying patient-specific cells and growth factors for treatment of volumetric muscle lossR01AR073822 · NIAMS · UNIVERSITY OF NEBRASKA LINCOLN · PI TAMAYOL, ALI · 2018 to 2022
$1.8M
Multifunctional dressing for treatment of diabetic woundsR01GM126831 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI DOKMECI, MEHMET REMZI, TAMAYOL, ALI · 2018 to 2021
$1.3M
Regenerative Engineering of Musculoskeletal Tissues- a Convergence Doctoral Training ProgramT32AR079114 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LAURENCIN, CATO T. · 2021 to 2025
$1.1M
NIAMS NIH HHS R01 AR073822NIAMS NIH HHS R01 AR077132NIAMS NIH HHS T32 AR079114NIGMS NIH HHS R01 GM126831
6 · The paper itself

Abstract

Cellular agriculture is an emerging field rooted in engineering meat-mimicking cell-laden structures using tissue engineering practices that have been developed for biomedical applications, including regenerative medicine. Research and industrial efforts are focused on reducing the cost and improving the throughput of cultivated meat (CM) production using these conventional practices. Due to key differences in the goals of muscle tissue engineering for biomedical versus food applications, conventional strategies may not be economically and technologically viable or socially acceptable. In this review, these two fields are critically compared, and the limitations of biomedical tissue engineering practices in achieving the important requirements of food production are discussed. Additionally, the possible solutions and the most promising biomanufacturing strategies for cellular agriculture are highlighted.

Indexed as

Biomedical EngineeringTissue EngineeringMusclesRegenerative Medicinebiomanufacturingbioreactorscultivated meatmedical tissue engineeringtechno-economic analysis

Identifiers

PMID36914431
PMCPMC11412388
OpenAlexW4323922630

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.