Evidence map›Paper›PMID 36914224›Full record

ArticleACS sensors2023

Signal Amplification in Electrochemical DNA Biosensors Using Target-Capturing DNA Origami Tiles.

Paul Williamson, Petteri Piskunen, Heini Ijäs, Adrian Butterworth, Veikko Linko, Damion K Corrigan

Abstract read
In one paragraph

Article in ACS sensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Modular DNA origami-based electrochemical detection of DNA and proteins.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. DNA Origami Vesicle Sensors with Triggered Single-Molecule Cargo Transfer.Angewandte Chemie (International ed. in English) · 2024
    Article
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paul WilliamsonDepartment of Biomedical Engineering, University of Strathclyde, Glasgow G1 1QE, United Kingdom.
Petteri PiskunenBiohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, 00076 Aalto, Finland.ORCID 0000-0002-3142-3191
Heini IjäsBiohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, 00076 Aalto, Finland.
Adrian ButterworthDepartment of Biomedical Engineering, University of Strathclyde, Glasgow G1 1QE, United Kingdom.ORCID 0000-0002-0463-927X
Veikko LinkoBiohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, 00076 Aalto, Finland.ORCID 0000-0003-2762-1555
Damion K CorriganDepartment of Biomedical Engineering, University of Strathclyde, Glasgow G1 1QE, United Kingdom.ORCID 0000-0002-4647-7483

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrochemical DNA (e-DNA) biosensors are feasible tools for disease monitoring, with their ability to translate hybridization events between a desired nucleic acid target and a functionalized transducer, into recordable electrical signals. Such an approach provides a powerful method of sample analysis, with a strong potential to generate a rapid time to result in response to low analyte concentrations. Here, we report a strategy for the amplification of electrochemical signals associated with DNA hybridization, by harnessing the programmability of the DNA origami method to construct a sandwich assay to boost charge transfer resistance (

Indexed as

Biosensing TechniquesElectrochemical TechniquesDNANucleic Acid HybridizationDNAantimicrobial resistance geneDNA hybridizationDNA nanotechnologyelectrochemical impedance spectroscopypoint-of-care devicessensitivity enhancementtarget selectivity

Identifiers

PMID36914224
PMCPMC10152479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.