Evidence map›Paper›PMID 36913444›Full record

Observational studyThe Journal of nutrition2023

Dietary Intake of Monosaccharides from Foods is Associated with Characteristics of the Gut Microbiota and Gastrointestinal Inflammation in Healthy US Adults.

Jules A Larke, Nikita Bacalzo, Juan J Castillo, Garret Couture, Ye Chen, Zhengyao Xue, Zeynep Alkan, Mary E Kable, Carlito B Lebrilla, Charles B Stephensen and 1 more

Registry-linked trialOpen access · greenAbstract readObservational Study
In one paragraph

Observational study in The Journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02367287 (Assessing the Impact of Diet on Inflammation in Healthy and Obese Adults in a Cross-Sectional Phenotyping Study), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02367287 completednot on this map

Assessing the Impact of Diet on Inflammation in Healthy and Obese Adults in a Cross-Sectional Phenotyping Study

TypeobservationalSponsorUSDA, Western Human Nutrition Research CenterRan2015 to 2019Enrolled393ConditionsObesity, Inflammation
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

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  9. Pyruvate kinase modulates the link between β-cell fructose metabolism and insulin secretion.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jules A LarkeUSDA-ARS Western Human Nutrition Research Center, Davis, CA, USA.
Nikita BacalzoDepartment of Chemistry, University of California, Davis, Davis, CA, USA.
Juan J CastilloDepartment of Chemistry, University of California, Davis, Davis, CA, USA.
Garret CoutureDepartment of Chemistry, University of California, Davis, Davis, CA, USA.
Ye ChenDepartment of Chemistry, University of California, Davis, Davis, CA, USA.
Zhengyao XueUSDA-ARS Western Human Nutrition Research Center, Davis, CA, USA; Department of Food Science and Technology, University of California, Davis, Davis, CA, USA.
Zeynep AlkanUSDA-ARS Western Human Nutrition Research Center, Davis, CA, USA.
Mary E KableUSDA-ARS Western Human Nutrition Research Center, Davis, CA, USA; Department of Nutrition, University of California, Davis, Davis, CA, USA.
Carlito B LebrillaDepartment of Chemistry, University of California, Davis, Davis, CA, USA; Department of Food Science and Technology, University of California, Davis, Davis, CA, USA.
Charles B StephensenUSDA-ARS Western Human Nutrition Research Center, Davis, CA, USA; Department of Nutrition, University of California, Davis, Davis, CA, USA.
Danielle G LemayUSDA-ARS Western Human Nutrition Research Center, Davis, CA, USA; Department of Nutrition, University of California, Davis, Davis, CA, USA. Electronic address: Danielle.Lemay@usda.gov.
Western Human Nutrition Research Center · USUniversity of California, Davis · US

Funding

Annotating carbohydrate structures to develop markers for consumption of foodR01DK124193 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEBRILLA, CARLITO B, LEMAY, DANIELLE GUYANNE · 2020 to 2024
$2.9M
NIDDK NIH HHS R01 DK124193
6 · The paper itself

Abstract

backgroundCurrent assessment of dietary carbohydrates does not adequately reflect the nutritional properties and effects on gut microbial structure and function. Deeper characterization of food carbohydrate composition can serve to strengthen the link between diet and gastrointestinal health outcomes.

objectivesThe present study aims to characterize the monosaccharide composition of diets in a healthy US adult cohort and use these features to assess the relationship between monosaccharide intake, diet quality, characteristics of the gut microbiota, and gastrointestinal inflammation.

methodsThis observational, cross-sectional study enrolled males and females across age (18-33 y, 34-49 y, and 50-65 y) and body mass index (normal, 18.5-24.99 kg/m

resultsDiversity of monosaccharide intake was positively associated with the total Healthy Eating Index score (Pearson's r = 0.520, P = 1.2 × 10

conclusionsMonosaccharide intake was associated with diet quality, gut microbial diversity, microbial metabolism, and gastrointestinal inflammation in healthy adults. As specific food sources were rich in particular monosaccharides, it may be possible in the future to tailor diets to fine-tune the gut microbiota and gastrointestinal function. This trial is registered at www. CLINICALTRIALS: gov as NCT02367287.

Indexed as

Gastrointestinal MicrobiomeAdultCross-Sectional StudiesDietDietary FiberEatingFecesFemaleHumansInflammationMaleMonosaccharidesDietary FiberMonosaccharidescarbohydratesdietary fiberdiet qualityglycangut inflammationgut microbiotahealthy adultsmonosaccharide

Identifiers

PMID36913444
PMCPMC10196574
OpenAlexW4313419271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.