ArticleEmerging microbes & infections2023
Prevalence, evolution, replication and transmission of H3N8 avian influenza viruses isolated from migratory birds in eastern China from 2017 to 2021.
Article in Emerging microbes & infections, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 22 citations in OpenAlex.
- Surveillance and biological characterization of H3 subtype avian influenza viruses in Eastern China.Virulence · 2026Article
- Global evolutionary landscape of H11 avian influenza and initial isolates identified in Xinjiang, China.Emerging microbes & infections · 2026Article
- Virulence and transmission characteristic of H3N8 avian influenza virus circulating in chickens in China.Virulence · 2026Article
- Genetic and Pathogenicity Studies of Avian Influenza (H9N2) Virus Isolated from Chickens in Jiangsu Province, China, in 2025.Microorganisms · 2026Article
- Long-Term Monitoring of Influenza A Viruses in Wild Waterfowl: Evidence from the Lake Baikal Basin (2018-2024).Viruses · 2026Article
- Dominant HA motif 131/132-NT shapes the phenotype of avian H9N2 influenza virus by modulating agglutination property, receptor specificity and infectivity in animals.Virologica Sinica · 2026Article
- Genetic evolutionary and pathogenicity analyses of a novel porcine reproductive and respiratory syndrome virus 1 strain SC202404 that emerged in Southwestern China.BMC veterinary research · 2026Article
- Surveillance of avian influenza viruses in migratory wild birds in South Korea, 2019-2025.Journal of veterinary science · 2026Article
- Isolation and characterization of a novel reassortant H3N8 avian influenza virus from chickens in Eastern China.Virus genes · 2026Article
- Epidemiology, evolution, and biological characteristics of H3 avian influenza viruses isolated from chickens in China.One health (Amsterdam, Netherlands) · 2025Article
- Article
- Exploring Avian Influenza Viruses in Yakutia-The Largest Breeding Habitat of Wild Migratory Birds in Northeastern Siberia.Viruses · 2025Article
- Characteristics of the First Domestic Duck-Origin H12N8 Avian Influenza Virus in China.International journal of molecular sciences · 2025Article
- Pathogenicity of Novel H3 Avian Influenza Viruses in Chickens and Development of a Promising Vaccine.Viruses · 2025Article
- Article
- Emergence of novel reassortant H3N3 avian influenza viruses with increased pathogenicity in chickens in 2023.Emerging microbes & infections · 2024Article
- Evolution and biological characteristics of H11 avian influenza viruses isolated from migratory birds and pigeons.Emerging microbes & infections · 2024Article
- In Silico Genomic Analysis of Avian Influenza Viruses Isolated From Marine Seal Colonies.Pathogens (Basel, Switzerland) · 2024Review
- Genetic and Biological Characteristics of Duck-Origin H4N6 Avian Influenza Virus Isolated in China in 2022.Viruses · 2024Article
- Immunogenic and Protective Properties of Recombinant Hemagglutinin of Influenza A (H5N8) Virus.Vaccines · 2024Article
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Authors and funding
18 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The continued evolution and emergence of novel influenza viruses in wild and domestic animals poses an increasing public health risk. Two human cases of H3N8 avian influenza virus infection in China in 2022 have caused public concern regarding the risk of transmission between birds and humans. However, the prevalence of H3N8 avian influenza viruses in their natural reservoirs and their biological characteristics are largely unknown. To elucidate the potential threat of H3N8 viruses, we analyzed five years of surveillance data obtained from an important wetland region in eastern China and evaluated the evolutionary and biological characteristics of 21 H3N8 viruses isolated from 15,899 migratory bird samples between 2017 and 2021. Genetic and phylogenetic analyses showed that the H3N8 viruses circulating in migratory birds and ducks have evolved into different branches and have undergone complicated reassortment with viruses in waterfowl. The 21 viruses belonged to 12 genotypes, and some strains induced body weight loss and pneumonia in mice. All the tested H3N8 viruses preferentially bind to avian-type receptors, although they have acquired the ability to bind human-type receptors. Infection studies in ducks, chickens and pigeons demonstrated that the currently circulating H3N8 viruses in migratory birds have a high possibility of infecting domestic waterfowl and a low possibility of infecting chickens and pigeons. Our findings imply that circulating H3N8 viruses in migratory birds continue to evolve and pose a high infection risk in domestic ducks. These results further emphasize the importance of avian influenza surveillance at the wild bird and poultry interface.
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