ArticleEnvironmental health perspectives2023
Association of Combined Exposure to Ambient Air Pollutants, Genetic Risk, and Incident Rheumatoid Arthritis: A Prospective Cohort Study in the UK Biobank.
Article in Environmental health perspectives, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- The Risk of Rheumatic Disorders Among Patients With Rhinosinusitis: A Systematic Review and Meta-Analysis.International forum of allergy & rhinology · 2025Pooled it
- The association between the residential environment and arthritis among the elderly in China: evidence from cohort and cross-sectional studies.Journal of global health · 2026Article
- Big Data May Have Big Pitfalls: Ensuring Rigor in Rheumatic Disease Epidemiology.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Environmental hazards and the risk of development of idiopathic urethral strictures.Translational andrology and urology · 2026Article
- Clonal haematopoiesis and risk of incident rheumatoid arthritis: results from the UK Biobank.Clinical and experimental rheumatology · 2026Article
- Global burden and inequalities of rheumatoid arthritis in adults aged 15-49 years from 1990 to 2021 and projections to 2050: a cross-sectional analysis from Global Burden of Disease Study 2021.Clinical rheumatology · 2026Article
- Late-Onset Rheumatoid Arthritis and Air Pollution in a Multiethnic Cohort.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Synergistic effects of ambient particulate matter and extreme weather events on arthritis risk: a prospective cohort study.BMC public health · 2026Article
- A Dual-Functioning Embolic Microsphere Platform for Combined Antiangiogenic and Anti-Inflammatory Therapy for Rheumatoid Arthritis.ACS omega · 2026Article
- Inhalant Exposures and the Risk of Rheumatoid Arthritis and Rheumatoid Arthritis-Associated Interstitial Lung Disease.Cardiovascular toxicology · 2026Review
- Air Pollution and Incident Cardiovascular Disease: Modification by Genetic Susceptibility and the Mitigating Role of Physical Activity.Journal of the American Heart Association · 2026Article
- Spatial analysis of physical activity and ambient air pollution in Kuwait: a cross-sectional study.Scientific reports · 2026Article
- PMAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Higher Grip Strength Is Associated With Reduced Risk of Incident Symptomatic Hand Osteoarthritis: Data From Two Cohort Studies.Journal of cachexia, sarcopenia and muscle · 2026Article
- Health Risk and Pathogenesis of PMToxics · 2026Review
- Air pollutants, genetic susceptibility, and the risk of age-related macular degeneration: a large prospective cohort study.European journal of epidemiology · 2026Article
- Plasma proteome mediates the associations between air pollution exposure and disease risk.Nature communications · 2026Article
- Association between mobile phone use and risk of rheumatoid arthritis: A large prospective cohort study.PloS one · 2026Article
- Plasma metabolomic and lipidomic signatures characteristic of treatment non-response in rheumatoid arthritis.Frontiers in immunology · 2026Article
- Evidence of immune-metabolic imbalance prior to sepsis: a prospective study in the UK Biobank.Frontiers in nutrition · 2026Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence for a potential link between air pollution and rheumatoid arthritis (RA) is inconsistent, and the modified effect of genetic susceptibility on the relationship between air pollution and RA has not been well studied.
objectiveUsing a general population cohort from the UK Biobank, this study aimed to investigate the associations between various air pollutants and the risk of incident RA and to further estimate the impact of combined exposure to ambient air pollutants on the risk of developing RA under the modification effect of genetic predisposition.
methodsA total of 342,973 participants with completed genotyping data and who were free of RA at baseline were included in the study. An air pollution score was constructed by summing the concentrations of each pollutant weighted by the regression coefficients with RA from single-pollutant models to assess the combined effect of air pollutants, including particulate matter (PM) with diameters
resultsDuring a median follow-up time of 8.1 y, 2,034 incident events of RA were recorded. The HRs (95% CIs) of incident RA per interquartile range increment in DISCUSSION: The results revealed that long-term combined exposure to ambient air pollutants might increase the risk of RA, particularly in those with high genetic risk. https://doi.org/10.1289/EHP10710.
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