Evidence map›Paper›PMID 36913068›Full record

ArticleCellular oncology (Dordrecht, Netherlands)2023

LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation.

Fei Shi, Lei Wu, Di Cui, Menghao Sun, Yuanhao Shen, Zheng Zhou, Zheng Deng, Bangmin Han, Shujie Xia, Zheng Zhu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular oncology (Dordrecht, Netherlands), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Fei ShiDepartment of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China.
Lei WuDepartment of Urology, Shanghai General Hospital, Nanjing Medical University, Shanghai, 200080, China.
Di CuiDepartment of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China.
Menghao SunDepartment of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China.
Yuanhao ShenSchool of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.
Zheng ZhouDepartment of Urology, Shanghai General Hospital, Nanjing Medical University, Shanghai, 200080, China.
Zheng DengDepartment of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China.
Bangmin HanDepartment of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China.
Shujie XiaDepartment of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China.
Zheng ZhuDepartment of Internal Medicine, Division of Hematology/Oncology, University of California Davis, Sacramento, CA, 95817, USA. zegzhu@ucdavis.edu.
Feng SunDepartment of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China. feng.sun@shgh.cn.
Shanghai First People's Hospital · CNShanghai Jiao Tong University · CNNanjing Medical University · CNShanghai Medical College of Fudan University · CNUniversity of California, Davis · US

Funding

"Chen Guang" project supported by the Shanghai Municipal Education Commission and Shanghai Education Development Foundation #16CG10Postgraduate Research & Practice Innovation Program of Jiangsu Province #KYCX22_1836Youth Fund Project of the National Natural Science Foundation #81602252
6 · The paper itself

Abstract

Accumulating evidence indicates that long noncoding RNAs (lncRNAs) are abnormal expression in various malignant tumors. Our previous research demonstrated that focally amplified long non-coding RNA (lncRNA) on chromosome 1 (FALEC) is an oncogenic lncRNA in prostate cancer (PCa). However, the role of FALEC in castration-resistant prostate cancer (CRPC) is poorly understood. In this study, we showed FALEC was upregulated in post-castration tissues and CRPC cells, and increased FALEC expression was associated with poor survival in post-castration PCa patients. RNA FISH demonstrated FALEC was translocated into nucleus in CRPC cells. RNA pulldown and followed Mass Spectrometry (MS) assay demonstrated FALEC directly interacted with PARP1 and loss of function assay showed FALEC depletion sensitized CRPC cells to castration treatment and restored NAD

Indexed as

Prostatic Neoplasms, Castration-ResistantRNA, Long NoncodingAnimalsHumansMaleMiceMice, Inbred NODMice, SCIDNADPoly (ADP-Ribose) Polymerase-1Poly ADP RibosylationNADPARP1 protein, humanPoly (ADP-Ribose) Polymerase-1RNA, Long NoncodingCastration-resistant prostate cancer (CRPC)lncFALECPARP1Self PARylation

Identifiers

PMID36913068
PMCPMC12974635
OpenAlexW4324020447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.