Evidence map›Paper›PMID 36912916›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2023

SOCS2 regulates alveolar bone loss in Aggregatibacter actinomycetemcomitans-induced periodontal disease.

Mariana Rates Gonzaga Santos, Ian de Meira Chaves, Celso Martins Queiroz-Junior, Allysson Thiago Cramer, Thales Augusto Anestino, Anna Clara Paiva Menezes Dos Santos, Paulo Gaio Leite, Soraia Macari, Breno Rocha Barrioni, Marivalda de Magalhães Pereira and 4 more

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In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Mariana Rates Gonzaga SantosDepartment of Biochemistry and Immunology, Institute of Biological Science, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Ian de Meira ChavesDepartment of Microbiology, Institute of Biological Science, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Celso Martins Queiroz-JuniorDepartment of Morphology, Institute of Biological Science, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Allysson Thiago CramerDepartment of Biochemistry and Immunology, Institute of Biological Science, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Thales Augusto AnestinoDepartment of Microbiology, Institute of Biological Science, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Anna Clara Paiva Menezes Dos SantosDepartment of Microbiology, Institute of Biological Science, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Paulo Gaio LeiteDepartment of Biochemistry and Immunology, Institute of Biological Science, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Soraia MacariDepartment of Restorative Dentistry, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Breno Rocha BarrioniDepartment of Metallurgical Engineering and Materials, School of Engineering, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Marivalda de Magalhães PereiraDepartment of Metallurgical Engineering and Materials, School of Engineering, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Mauro Martins TeixeiraDepartment of Biochemistry and Immunology, Institute of Biological Science, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Danielle da Glória de SouzaDepartment of Microbiology, Institute of Biological Science, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Mila Fernandes Moreira Madeira *Department of Microbiology, Institute of Biological Science, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. milamadeira@icb.ufmg.br.
Fabiana Simão MachadoDepartment of Biochemistry and Immunology, Institute of Biological Science, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. machadofs@icb.ufmg.br.
Universidade Federal de Minas Gerais · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 307981/2014-2Conselho Nacional de Desenvolvimento Científico e Tecnológico 408433/2018-3Fundação de Amparo a Pesquisa de Minas Gerais REDE-00140-16National Institute for Science and Technology in Dengue and Host-microbial interactions APQ-03606-17
6 · The paper itself

Abstract

introductionThe role of suppressor of cytokine signaling 2 (SOCS2) in Aggregatibacter actinomycetemcomitans (Aa)-induced alveolar bone loss is unknown; thus, it was investigated in this study.

methodsAlveolar bone loss was induced by infecting C57BL/6 wild-type (WT) and Socs2-knockout (Socs2

resultsSocs2

conclusionsCollectively, data suggest that SOCS2 is a regulator of Aa-induced alveolar bone loss by controlling the differentiation and activity of bone cells, and proinflammatory cytokines availability in the periodontal microenvironment and an important target for new therapeutic strategies. Thus, it can be helpful in preventing alveolar bone loss in periodontal inflammatory conditions.

Indexed as

Alveolar Bone LossPeriodontal DiseasesAggregatibacter actinomycetemcomitansAnimalsCytokinesMiceMice, Inbred C57BLOsteoclastsSuppressor of Cytokine Signaling ProteinsCytokinesSocs2 protein, mouseSuppressor of Cytokine Signaling ProteinsAggregatibacter actinomycetemcomitansImmunoregulationOsteoclastogenesisPeriodontitisSOCS2

Identifiers

PMID36912916
OpenAlexW4324019039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.