Evidence map›Paper›PMID 36912775›Full record

ArticleeLife2023

Evidence for embracing normative modeling.

Saige Rutherford, Pieter Barkema, Ivy F Tso, Chandra Sripada, Christian F Beckmann, Henricus G Ruhe, Andre F Marquand

Registry-linked trialFull text read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06396520 (Neuroimaging of Babies During Natural Sleep to Assess Typical Development and Cerebral Palsy), which is not on this map. Cited by 101 papers.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06396520 recruitingnot on this mapstarted 2024, after this paper: background citation

Neuroimaging of Babies During Natural Sleep to Assess Typical Development and Cerebral Palsy

TypeobservationalSponsorDanish Research Centre for Magnetic ResonanceRan2024 to 2027Enrolled200ConditionsCerebral Palsy, Infant Development, Development, InfantArmsNo intervention, observational
3 · Its place in the literature

Who cites it

101 citing papers in PubMed.

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  20. Normative Modeling of Static and Dynamic Functional Connectivity.bioRxiv : the preprint server for biology · 2026
    Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Saige RutherfordDepartment of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands.ORCID 0000-0003-3006-9044
Pieter BarkemaDonders Institute, Radboud University Nijmegen, Nijmegen, Netherlands.
Ivy F TsoDepartment of Psychiatry, University of Michigan-Ann Arbor, Ann Arbor, United States.
Chandra SripadaDepartment of Psychiatry, University of Michigan-Ann Arbor, Ann Arbor, United States.ORCID 0000-0001-9025-6453
Christian F Beckmann *Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands.
Henricus G Ruhe *Donders Institute, Radboud University Nijmegen, Nijmegen, Netherlands.
Andre F Marquand *Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands.

Funding

Establishing Network Neuroscience Mechanisms of Efficiency of Evidence Accumulation in a Well-Characterized Sample with Bipolar Disorder: A Multi-Modal Clinical Imaging StudyR01MH130348 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Chandra Sekhar Sripada · 2022 to 2026
$3.6M
Disrupted eye gaze perception as a biobehavioral marker of social dysfunction: An RDoC investigationR01MH122491 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TSO, IVY FEI · 2020 to 2024
$2.9M
Building a multi-factor etiological model of the emergence of general psychopathology (the "P factor") in adolescence with multi-modal neuroimaging in ABCDR01MH123458 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SRIPADA, CHANDRA SEKHAR · 2021 to 2025
$1.9M
Neural mechanisms of eye gaze perception in schizophreniaK23MH108823 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TSO, IVY FEI · 2016 to 2020
$894k
NIMH NIH HHS K23 MH108823NIMH NIH HHS R01 MH122491NIMH NIH HHS R01MH122491NIMH NIH HHS R01 MH123458NIMH NIH HHS R01MH123458NIMH NIH HHS R01 MH130348NIMH NIH HHS R01MH130348Wellcome TrustWellcome Trust 098369/Z/12/ZWellcome Trust 215698/Z/19/Z
6 · The paper itself

Abstract

In this work, we expand the normative model repository introduced in Rutherford et al., 2022a to include normative models charting lifespan trajectories of structural surface area and brain functional connectivity, measured using two unique resting-state network atlases (Yeo-17 and Smith-10), and an updated online platform for transferring these models to new data sources. We showcase the value of these models with a head-to-head comparison between the features output by normative modeling and raw data features in several benchmarking tasks: mass univariate group difference testing (schizophrenia versus control), classification (schizophrenia versus control), and regression (predicting general cognitive ability). Across all benchmarks, we show the advantage of using normative modeling features, with the strongest statistically significant results demonstrated in the group difference testing and classification tasks. We intend for these accessible resources to facilitate the wider adoption of normative modeling across the neuroimaging community.

Indexed as

Magnetic Resonance ImagingSchizophreniaBrainHumansNeuroimagingbrain chartscomputational psychiatryfunctional neuroimagingheterogeneityhumanindividual predictionmachine learningneuroscience

Identifiers

PMID36912775
PMCPMC10036120

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.