ArticleJournal of visualized experiments : JoVE2023
Measuring Embryonic Viability and Brood Size in Caenorhabditis elegans.
Article in Journal of visualized experiments : JoVE, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Peptone-free nematode growth medium improves culture stability and physiological resilience in Caenorhabditis elegans.Biogerontology · 2026Article
- HDAC1/2-mediated repression of Wnt receptor expression orients asymmetric division polarity in Caenorhabditis elegans.Development (Cambridge, England) · 2026Article
- Machine Learning-Accelerated Analysis ofResearch square · 2026Article
- Bioinformatics analysis of the sodium-dependent neurotransmitter transporter family in Bursaphelenchus xylophilus.BMC genomics · 2026Article
- A robust, high-content NAM for repeatable and predictive developmental and reproductive toxicity assessment in C. elegans.Scientific reports · 2026Article
- SPSP-1 is a sperm protein required for C. elegans hermaphrodite sperm production and embryogenesis.Biology open · 2026Article
- Quantifying Embryonic Lethality Rate in Caenorhabditis elegans.Journal of visualized experiments : JoVE · 2026Article
- A Robust, High-Content NAM for Repeatable and Predictive Developmental and Reproductive Toxicity Assessment in C. elegans.Research square · 2026Article
- Oocyte surface proteins EGG-1 and EGG-2 are required for eggshell integrity in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2026Article
- A C. elegans model of familial Alzheimer's disease shows age-dependent synaptic degeneration independent of amyloid β-peptide.Neurobiology of disease · 2026Article
- CHK1 inhibition rescues abnormal glycogen buildup in a Caenorhabditis elegans model for glycogen storage disease III.Communications biology · 2026Article
- Caenorhabditis elegans as an experimental model for resilience-boosting microbiota interventions in nonmodel ectotherms.FEMS microbiology reviews · 2026Review
- Short-term L1 arrest duration does not significantly alter organismal phenotypes in synchronizedmicroPublication biology · 2026Article
- Spatial Partitioning of Core Glycolysis Enables Tissue-Specific Metabolic Programs In Vivo.bioRxiv : the preprint server for biology · 2025Article
- Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration.Nature cell biology · 2025Article
- Phosphatidylinositol 4,5-bisphosphate impacts extracellular vesicle shedding from C. elegans ciliated sensory neurons.Journal of cell science · 2025Article
- Oocyte surface proteins EGG-1 and EGG-2 are required for eggshell integrity inbioRxiv : the preprint server for biology · 2025Article
- Phosphatidylinositol 4,5-bisphosphate Impacts Extracellular Vesicle Shedding frombioRxiv : the preprint server for biology · 2025Article
- Gut microbiome speciesCurrent research in microbial sciences · 2025Article
- Herbo-Mineral Medicine, Cardiogrit Gold, Exhibits Protective Effects inJournal of toxicology · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Caenorhabditis elegans is an excellent model organism for the study of meiosis, fertilization, and embryonic development. C. elegans exist as self-fertilizing hermaphrodites, which produce large broods of progeny-when males are present, they can produce even larger broods of cross progeny. Errors in meiosis, fertilization, and embryogenesis can be rapidly assessed as phenotypes of sterility, reduced fertility, or embryonic lethality. This article describes a method to determine embryonic viability and brood size in C. elegans. We demonstrate how to set up this assay by picking a worm onto an individual Modified Youngren's, Only Bacto-peptone (MYOB) plate, establish the appropriate timeframe to count viable progeny and non-viable embryos, and explain how to accurately count live worm specimens. This technique can be used to determine viability in self-fertilizing hermaphrodites as well as cross-fertilization by mating pairs. These relatively simple experiments are easily adoptable for new researchers, such as undergraduate students and first-year graduate students.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.