Trial reportStroke2023
Transcranial Direct-Current Stimulation in Subacute Aphasia: A Randomized Controlled Trial.
Trial report in Stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02674490 (Effects of Transcranial Direct Current Stimulation), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Transcranial Direct Current Stimulation (tDCS) Plus Language Therapy for Naming in Subacute Left Hemisphere Stroke
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Does SLT combined with NIBS enhance naming recovery in post-stroke aphasia? A meta-analysis and systematic review.NeuroRehabilitation · 2024Pooled it
- Neuromodulation for Post-Stroke Motor Recovery: a Narrative Review of Invasive and Non‑Invasive Tools.Current neurology and neuroscience reports · 2023Pooled it
- tDCS and Speech Therapy in Aphasia Treatment: A Multicenter Comparative Study of Efficacy.Medical science monitor : international medical journal of experimental and clinical research · 2025Trial
- ORLA combined with telerehabilitation in patients with subacute Poststroke aphasia: a randomized controlled trial.Scientific reports · 2025Trial
- Microstructural properties in subacute aphasia: concurrent and prospective relationships underpinning recovery.Brain structure & function · 2024Trial
- Individual Differences in Response to Transcranial Direct Current Stimulation With Language Therapy in Subacute Stroke.Neurorehabilitation and neural repair · 2023Trial
- White matter predictors of cerebellar tDCS treatment effects in aphasia rehabilitation.Frontiers in neurologyTrial
- The Impact of Anodal tDCS on Verbal and Nonverbal Functional Communication in Subacute Aphasia-An Observational Study.Brain sciences · 2026Article
- Lipid metabolism, microglia, and stroke.Neural regeneration research · 2026Article
- Acute-Phase Machine Learning Prediction of 12-Month Aphasia and Discourse Recovery.medRxiv : the preprint server for health sciences · 2026Article
- PICTURE-IT: a pilot randomized cross-over trial encouraging right-hemisphere engagement for the treatment of aphasia via telemedicine.Aphasiology · 2025Article
- Non-invasive brain stimulation: current and future applications in neurology.Nature reviews. Neurology · 2025Review
- Cognitive Functions Supporting Learning Over Time in Naming Treatment for Aphasia.Journal of speech, language, and hearing research : JSLHR · 2025Article
- Advances in Neuromodulation Techniques for Aphasia Rehabilitation: A Comprehensive Review.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Measuring severe stroke: a scoping review of RCTs.Frontiers in neurology · 2025Review
- The impact of brain-derived neurotrophic factor gene polymorphisms on post-stroke naming in aphasia.PloS one · 2025Article
- Early Boost of Linguistic Skills? Individualized Non-Invasive Brain Stimulation in Early Postacute Aphasia.Brain sciences · 2024Article
- Advances in Stroke Neurorehabilitation.Journal of clinical medicine · 2023Review
- Subacute aphasia recovery is associated with resting-state connectivity within and beyond the language network.Annals of clinical and translational neurology · 2023Article
- Supporting Post-Stroke Language and Cognition with Pharmacotherapy: Tools for Each Phase of Care.Current neurology and neuroscience reports · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundTranscranial direct-current stimulation (tDCS) is a promising adjunct to therapy for chronic aphasia.
methodsThis single-center, randomized, double-blind, sham-controlled efficacy trial tested the hypothesis that anodal tDCS augments language therapy in subacute aphasia. Secondarily, we compared the effect of tDCS on discourse measures and quality of life and compared the effects on naming to previous findings in chronic stroke. Right-handed English speakers with aphasia <3 months after left hemisphere ischemic stroke were included, unless they had prior neurological or psychiatric disease or injury or were taking certain medications (34 excluded; final sample, 58). Participants were randomized 1:1, controlling for age, aphasia type, and severity, to receive 20 minutes of tDCS (1 mA) or sham-tDCS in addition to fifteen 45-minute sessions of naming treatment (plus standard care). The primary outcome variable was change in naming accuracy of untrained pictures pretreatment to 1-week posttreatment.
resultsBaseline characteristics were similar between the tDCS (N=30) and sham (N=28) groups: patients were 65 years old, 53% male, and 2 months from stroke onset on average. In intent-to-treat analysis, the adjusted mean change from baseline to 1-week posttreatment in picture naming was 22.3 (95% CI, 13.5-31.2) for tDCS and 18.5 (9.6-27.4) for sham and was not significantly different. Content and efficiency of picture description improved more with tDCS than sham. Groups did not differ in quality of life improvement. No patients were withdrawn due to adverse events.
conclusionstDCS did not improve recovery of picture naming but did improve recovery of discourse. Discourse skills are critical to participation. Future research should examine tDCS in a larger sample with richer functional outcomes. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT02674490.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.