ArticleStroke2023
Dissociable Contributions of Thalamic-Subregions to Cognitive Impairment in Small Vessel Disease.
Article in Stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Associations between structural brain alterations and dysfunction across cognitive domains in cerebral small vessel disease: A systematic review and meta-analysis.Neuroimage. Reports · 2026Review
- Charting brain morphology in international healthy and neurological populations.Nature neuroscience · 2026Article
- Thalamic microstructural alterations in cerebral small vessel disease with mild cognitive impairment: insights from diffusion kurtosis imaging.Neuroradiology · 2025Article
- Altered brain structural covariance networks of the thalamic subfields in right chronic capsular stroke.Frontiers in neuroscience · 2025Article
- The thalamic covariance network is associated with cognitive deficits in patients with cerebral small vascular disease.Annals of clinical and translational neurology · 2024Article
- Thalamic functional dysconnectivity in patients with left-hemisphere chronic capsular and pontine stroke.Frontiers in neuroscience · 2024Article
- Aberrant baseline brain activity and disrupted functional connectivity in patients with vascular cognitive impairment due to cerebral small vessel disease.Frontiers in neurology · 2024Article
- Unraveling the link: white matter damage, gray matter atrophy and memory impairment in patients with subcortical ischemic vascular disease.Frontiers in neuroscience · 2024Article
- Regional cortical thinning, demyelination and iron loss in cerebral small vessel disease.Brain : a journal of neurology · 2023Article
- Implications of fitting a two-compartment model in single-shell diffusion MRI.Physics in medicine and biology · 2023Article
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Authors and funding
10 authors at 2 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStructural network damage is a potentially important mechanism by which cerebral small vessel disease (SVD) can cause cognitive impairment. As a central hub of the structural network, the role of thalamus in SVD-related cognitive impairments remains unclear. We aimed to determine the associations between the structural alterations of thalamic subregions and cognitive impairments in SVD.
methodsIn this cross-sectional study, 205 SVD participants without thalamic lacunes from the third follow-up (2020) of the prospective RUN DMC study (Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort), which was initiated in 2006, Nijmegen, were included. Cognitive functions included processing speed, executive function, and memory. Probabilistic tractography was performed from thalamus to 6 cortical regions, followed by connectivity-based thalamic segmentation to assess each thalamic subregion volume and connectivity (measured by mean diffusivity [MD] of the connecting white matter tracts) with the cortex. Least absolute shrinkage and selection operator regression analysis was conducted to identify the volumes or connectivity of the total thalamus and 6 thalamic subregions that have the strongest association with cognitive performance. Linear regression and mediation analyses were performed to test the association of least absolute shrinkage and selection operator-selected thalamic subregion volume or MD with cognitive performance, while adjusting for age and education.
resultsWe found that higher MD of the thalamic-motor tract was associated with worse processing speed (β=-0.27;
conclusionsOur results suggest that the structural alterations of thalamus are linked to cognitive impairment in SVD, largely depending on the damage pattern of the white matter tracts connecting specific thalamic subregions and cortical regions.
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