Evidence map›Paper›PMID 36911626›Full record

ArticleDNA2022

Size- and Stereochemistry-Dependent Transcriptional Bypass of DNA Alkyl Phosphotriester Adducts in Mammalian Cells.

Ying Tan, Jiabin Wu, Garrit Clabaugh, Lin Li, Hua Du, Yinsheng Wang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in DNA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Formation of Carboxymethyl-Phosphotriester Adducts in DNA.Chemical research in toxicology · 2025
    Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ying TanEnvironmental Toxicology Graduate Program, University of California Riverside, Riverside, CA 92521-0403, USA.
Jiabin WuEnvironmental Toxicology Graduate Program, University of California Riverside, Riverside, CA 92521-0403, USA.
Garrit ClabaughDepartment of Chemistry, University of California Riverside, Riverside, CA 92521-0403, USA.
Lin LiDepartment of Chemistry, University of California Riverside, Riverside, CA 92521-0403, USA.
Hua DuDepartment of Chemistry, University of California Riverside, Riverside, CA 92521-0403, USA.
Yinsheng WangEnvironmental Toxicology Graduate Program, University of California Riverside, Riverside, CA 92521-0403, USA.ORCID 0000-0001-5565-283X
University of California, Riverside · US

Funding

Research Training in Environmental ToxicologyT32ES018827 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Yinsheng Wang · 2010 to 2026
$5.3M
Chemistry and Biology of Alkyl Phosphotriester LesionsR01CA236204 · NCI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI WANG, YINSHENG · 2020 to 2024
$1.8M
NCI NIH HHS R01 CA236204NIEHS NIH HHS T32 ES018827
6 · The paper itself

Abstract

Environmental, endogenous and therapeutic alkylating agents can react with internucleotide phosphate groups in DNA to yield alkyl phosphotriester (PTE) adducts. Alkyl-PTEs are induced at relatively high frequencies and are persistent in mammalian tissues; however, their biological consequences in mammalian cells have not been examined. Herein, we assessed how alkyl-PTEs with different alkyl group sizes and stereochemical configurations (

Indexed as

DNA alkylationDNA damagetranscriptional mutagenesis

Identifiers

PMID36911626
PMCPMC9997456
OpenAlexW4303628079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.