ArticleFrontiers in pediatrics2023
Gut microbiota composition alteration analysis and functional categorization in children with growth hormone deficiency.
Article in Frontiers in pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Gut microbiota profiles in Korean children with growth hormone deficiency: a case-control study.Clinical and experimental pediatrics · 2026Article
- Children with idiopathic short stature and growth hormone deficiency exhibit similar changes in gut microbiota.Endocrine journal · 2025Article
- Influence of gut microbiota on the pediatric endocrine system and associated disorders.Annals of medicine and surgery (2012) · 2025Review
- Gut microbiome and short-chain fatty acids associated with the efficacy of growth hormone treatment in children with short stature.Frontiers in pediatrics · 2025Article
- Gut-brain-liver axis in growth hormone deficiency: role of microbiota-derived short-chain fatty acids in ethnic variability and therapeutic development.Frontiers in public health · 2025Review
- Impact of different growth hormone levels on gut microbiota and metabolism in short stature.Pediatric research · 2024Article
- Characteristics of intestinal microbiota in children with idiopathic short stature: a cross-sectional study.European journal of pediatrics · 2023Article
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Authors and funding
9 authors.
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Abstract
Objective: To study changes in the composition and functions of the gut microbiota (GM) in children with growth hormone deficiency (GHD) using high-throughput sequencing. Methods: Thirty-three children with GHD diagnosed in Longgang District Maternity and Child Health Hospital were included in the disease group and 24 healthy children of the same age comprised the control group. Total DNA was extracted and amplified from stool samples obtained from all subjects. High-throughput sequencing was used to analyze the GM composition and functions. Results: The GM from the two groups of children showed significant differences in α-diversity ( Conclusion: Significant alterations in the GM are seen in children with growth hormone deficiency, which may affect both energy metabolism and the levels of endocrine hormones, potentially leading to growth restriction.
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