Evidence map›Paper›PMID 36910891›Full record

ArticleInternational journal of clinical and experimental pathology2023

Pathologic evaluation of lumpectomy resection margins for invasive breast cancer: a single institution's experience.

Yong Zhang, Jie Wu, Wei Huang, Ying Wang, Lidys Rivera Galvis, Tiane Chen, Bing Han

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PubMed Full text at PMC
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Article in International journal of clinical and experimental pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yong ZhangDepartment of Pathology and Laboratory Medicine, Penn State Health Milton S. Hershey Medical Center, Penn State College of Medicine Hershey, PA 17033, USA.
Jie WuDepartment of Pathology, Shanghai Jiahui International Hospital Xuhui District, Shanghai 200233, China.
Wei HuangDepartment of Pathology and Laboratory Medicine, Penn State Health Milton S. Hershey Medical Center, Penn State College of Medicine Hershey, PA 17033, USA.
Ying WangDepartment of Pathology and Laboratory Medicine, Penn State Health Milton S. Hershey Medical Center, Penn State College of Medicine Hershey, PA 17033, USA.
Lidys Rivera GalvisDepartment of Pathology and Laboratory Medicine, Penn State Health Milton S. Hershey Medical Center, Penn State College of Medicine Hershey, PA 17033, USA.
Tiane ChenDepartment of Pathology and Laboratory Medicine, Penn State Health Milton S. Hershey Medical Center, Penn State College of Medicine Hershey, PA 17033, USA.
Bing HanDepartment of Pathology and Laboratory Medicine, Penn State Health Milton S. Hershey Medical Center, Penn State College of Medicine Hershey, PA 17033, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesBreast conservation therapy (BCT) or lumpectomy followed by radiation has been established as a preferred treatment for most patients with early-stage invasive breast cancer. About 20-40% of patients after initial lumpectomy will have to undergo re-excision due to a positive margin.

methodsTo determine the factors predicting higher risk of positive resection margin, we retrospectively analyzed 409 patients who underwent initial lumpectomy for invasive breast cancer from January 2019 through November 2022. Based on microscopic examination, the samples were divided into 3 subgroups with positive, close, or clean margins.

resultsPositive margin was more frequently associated with larger tumor size (P<0.0001), specified histologic type (P<0.0001), higher tumor grade (P=0.004), multifocality (P<0.0001), positive lymph node status (P=0.0005), and lymphovascular invasion (P=0.0007). Other factors were not significantly associated with margin status including HER2/ER/PR status, presence of carcinoma in situ component, age at diagnosis, and history of neoadjuvant chemotherapy.

conclusionsFrom the clinical practice of individual institution, identification and comprehensive assessment of these pathologic predictors will be useful for clinical management and intraoperative surgical-decision-making to reduce the rate of re-excision.

Indexed as

invasive breast cancerLumpectomymargin statuspathologic factors

Identifiers

PMID36910891
PMCPMC9993018

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