ArticleSexual medicine2023
Case series: expanding diagnostic markers in postorgasmic illness syndrome.
Article in Sexual medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Data-Driven symptom clustering identifies four potential phenotypes of self-reported postorgasmic illness syndrome: findings from a large Chinese online survey.International journal of impotence research · 2026Article
- Recognition and practice patterns of sexual medicine experts towards postorgasmic illness syndrome.International journal of impotence research · 2025Article
- Postorgasmic illness syndrome benefiting from omalizumab and antidepressant: a case report.Journal of medical case reports · 2024Article
- Post-orgasmic Illness Syndrome: A Case Report.Cureus · 2024Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Postorgasmic illness syndrome (POIS) is a rare condition in which individuals develop generalized and flu-like symptoms after ejaculation. Several mechanisms and treatments for this disorder have been proposed but many questions remain. Aims: We sought to present a summary of literature to date and highlight common symptoms, associated features, comorbidities, and laboratory findings in a clinical sample of patients with POIS. Methods: We conducted a retrospective chart review of 6 patients with POIS in our clinic and presented compiled results. Results: We identified newly described non-flu-like presentations, onset of symptoms with high states of arousal without ejaculation, and presence of psychiatric comorbidity in a majority of patients. We did not identify a postorgasm allergic response with bloodwork available. Conclusion: POIS remains a poorly understood condition that likely comprises a number of different clinical entities. Further research on a larger clinical sample is necessary to better characterize POIS and understand its biological and psychological basis.
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