Evidence map›Paper›PMID 36910630›Full record

ArticleFrontiers in oncology2023

Case report: Complete and durable response to larotrectinib (TRK inhibitor) in an infant diagnosed with angiosarcoma harbouring a

Catherine Cervi, Zoltán Sápi, Gábor Bedics, Erik Zajta, Lajos Hegyi, Judit Pápay, Katalin Dezső, Edit Varga, Katalin Mudra, Csaba Bödör and 1 more

Abstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. A NovelPediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Catherine CerviDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Zoltán SápiDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Gábor BedicsDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Erik ZajtaDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Lajos HegyiDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Judit PápayDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Katalin DezsőDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Edit Varga2nd Department of Paediatrics, Semmelweis University, Budapest, Hungary.
Katalin Mudra2nd Department of Paediatrics, Semmelweis University, Budapest, Hungary.
Csaba BödörDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Monika Csóka2nd Department of Paediatrics, Semmelweis University, Budapest, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Significant improvements in the survival rates of paediatric cancer have been achieved over the past decade owing to recent advances in therapeutic and diagnostic strategies. However, disease progression and relapse remain a major challenge for the clinical management of paediatric angiosarcoma. Comprehensive genomic profiling of these rare tumours using high-throughput sequencing technologies may improve patient stratification and identify actionable biomarkers for therapeutic intervention. Here, we describe the clinical, histopathological, immunohistochemical and molecular profile of a novel and precision medicine-informed case where a

Indexed as

angiosarcomacomprehensive genomic profiling (CGP)larotrectinibneurotrophic tyrosine receptor kinase (NTRK)next-generation sequencing (NGS)NTRK fusion genepaediatric soft tissue sarcomaprecision oncology

Identifiers

PMID36910630
PMCPMC9997097

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.