ArticleThe World Allergy Organization journal2023
WAO consensus on DEfinition of Food Allergy SEverity (DEFASE).
Article in The World Allergy Organization journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Prevalence of Avoidant/Restrictive Food Intake Disorder (ARFID) in children with and without food allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Almond Allergy in Children and Adults: A Narrative Review of Current Knowledge, Clinical Challenges, and Research Gaps.Nutrients · 2026Review
- Seed-Borne Spirosoma pollinicola in Commercial Hazelnuts: A Global Survey of Microbial Presence and Allergen Diversity.Plant, cell & environment · 2026Article
- Evaluation of the Antihistamine and Anti-Inflammatory Effects of a Nutraceutical Blend Based on Quercetin,Current issues in molecular biology · 2025Article
- Food allergy severity across the world: A World Allergy Organization international survey.The World Allergy Organization journal · 2025Article
- Korean red ginseng extract suppresses food allergy by remodeling the gut microbiota and restoring immune homeostasis in IL4raJournal of ginseng research · 2025Article
- A World Allergy Organization (WAO) manifesto for the worldwide approval of biologic therapies for food allergy.The World Allergy Organization journal · 2025Article
- Common data elements for food allergy clinical trials: an overview.Current opinion in allergy and clinical immunology · 2025Review
- Omalizumab in Food Allergy in Children: Current Evidence and Future Perspectives.Life (Basel, Switzerland) · 2025Review
- Etiological Patterns of Protein-Energy Malnutrition in a Pediatric Clinic in China.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Evolving Food Allergy Clinical Trials to Become More Patient-Centered.The journal of allergy and clinical immunology. In practice · 2025Review
- The Psychosocial Burden of Pediatric Food Allergy in the United States: A Population-Based Survey.The journal of allergy and clinical immunology. In practice · 2025Article
- Management of children with food allergies by allergists in the United States.The journal of allergy and clinical immunology. Global · 2025Article
- Allergic manifestations in inborn errors of immunity: a systematic scoping review.Frontiers in immunology · 2025Article
- Parental knowledge and attitudes toward food allergies: a cross-sectional study on determinants and educational needs.BMC public health · 2024Article
- Navigating the landscape of food allergies: Insights and perspectives from the AMCP Market Insights Program.Journal of managed care & specialty pharmacy · 2024Article
- Anaphylaxis: Definition and criteria.Journal of food allergy · 2024Article
- Worldwide Heterogeneity of Food Allergy: Focus on Peach Allergy in Southern Italy.Journal of clinical medicine · 2024Review
- History of food allergy and where we are today.The World Allergy Organization journal · 2024Review
- The clinical burden of food allergies: Insights from the Food Allergy Research & Education (FARE) Patient Registry.The World Allergy Organization journal · 2024Article
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Authors and funding
51 authors.
Funding
Abstract
Background: While several scoring systems for the severity of anaphylactic reactions have been developed, there is a lack of consensus on definition and categorisation of severity of food allergy disease as a whole. Aim: To develop an international consensus on the severity of food allergy (DEfinition of Food Allergy Severity, DEFASE) scoring system, to be used globally. Methods Phase 1: We conducted a mixed-method systematic review (SR) of 11 databases for published and unpublished literature on severity of food allergy management and set up a panel of international experts. Phase 2: Based on our findings in Phase 1, we drafted statements for a two-round modified electronic Delphi (e-Delphi) survey. A purposefully selected multidisciplinary international expert panel on food allergy (n = 60) was identified and sent a structured questionnaire, including a set of statements on different domains of food allergy severity related to symptoms, health-related quality of life, and economic impact. Participants were asked to score their agreement on each statement on a 5-point Likert scale ranging from "strongly agree" to "strongly disagree". Median scores and percentage agreements were calculated. Consensus was defined Results: We received responses from 92% of Delphi panel members in round 1 and 85% in round 2. Consensus was achieved on the overall score and in all of the 5 specific key domains as essential components of the DEFASE score. Conclusions: The DEFASE score is the first comprehensive grading of food allergy severity that considers not only the severity of a single reaction, but the whole disease spectrum. An international consensus has been achieved regarding a scoring system for food allergy disease. It offers an evaluation grid, which may help to rate the severity of food allergy. Phase 3 will involve validating the scoring system in research settings, and implementing it in clinical practice.
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