Evidence map›Paper›PMID 36910591›Full record

ArticleAdvanced genetics (Hoboken, N.J.)2023

Mendelian Disorders in an Interstitial Cystitis/Bladder Pain Syndrome Cohort.

Elicia Estrella, Shira Rockowitz, Marielle Thorne, Pressley Smith, Jeanette Petit, Veronica Zehnder, Richard N Yu, Stuart Bauer, Charles Berde, Pankaj B Agrawal and 4 more

Registry-linked trialOpen access · goldFull text read
In one paragraph

Article in Advanced genetics (Hoboken, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00389142 (Genetic Studies in Interstitial Cystitis/Bladder Pain Syndrome), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00389142 recruitingnot on this map

Genetic Studies in Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)

TypeobservationalSponsorBoston Children's HospitalRan2006 to 2030Enrolled1,000ConditionsInterstitial Cystitis, Bladder Pain Syndrome
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Elicia EstrellaDepartment of Neurology Boston Children's Hospital Harvard Medical School Boston MA 02115 USA.
Shira RockowitzThe Manton Center for Orphan disease Research Boston Children's Hospital Harvard Medical School Boston MA 02115 USA.
Marielle ThorneDivision of Genetics and Genomics Boston Children's Hospital Harvard Medical School Boston MA 02115 USA.
Pressley SmithDivision of Genetics and Genomics Boston Children's Hospital Harvard Medical School Boston MA 02115 USA.
Jeanette PetitDivision of Genetics and Genomics Boston Children's Hospital Harvard Medical School Boston MA 02115 USA.
Veronica ZehnderDivision of Genetics and Genomics Boston Children's Hospital Harvard Medical School Boston MA 02115 USA.
Richard N YuDepartment of Urology Boston Children's Hospital Boston MA 02115 USA.
Stuart BauerDepartment of Urology Boston Children's Hospital Boston MA 02115 USA.
Charles BerdeThe Manton Center for Orphan disease Research Boston Children's Hospital Harvard Medical School Boston MA 02115 USA.
Pankaj B AgrawalDivision of Genetics and Genomics Boston Children's Hospital Harvard Medical School Boston MA 02115 USA.
Alan H BeggsDivision of Genetics and Genomics Boston Children's Hospital Harvard Medical School Boston MA 02115 USA.ORCID https://orcid.org/0000-0001-8818-0568
Ali G GharaviInstitute for Genomic Medicine Vagelos College of Physicians & Surgeons Columbia University New York NY 10032 USA.
Louis KunkelDivision of Genetics and Genomics Boston Children's Hospital Harvard Medical School Boston MA 02115 USA.
Catherine A BrownsteinDivision of Genetics and Genomics Boston Children's Hospital Harvard Medical School Boston MA 02115 USA.ORCID https://orcid.org/0000-0002-7371-0340
Boston Children's Hospital · USColumbia University · US

Funding

Transcriptional Regulation of Urothelial Differentiation During Homeostasis and Repair in Response to Urinary Tract InfectionU54DK104309 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JONATHAN M. BARASCH, ALI G GHARAVI · 2014 to 2026
$17.7M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Large-Scale Evaluation of the Effect of Rare Genetic Variants on Psychiatric Symptoms and Cognitive AbilityU01MH119690 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI ALMASY, LAURA A., GLAHN, DAVID C · 2019 to 2023
$5.9M
Epidemiological analysis of two interstitial cystitis cohortsU01DP006634 · DP · BOSTON CHILDREN'S HOSPITAL · PI BROWNSTEIN, CATHERINE ASTRID · 2021 to 2023
$2.5M
NCCDPHP CDC HHS U01 DP006634NICHD NIH HHS P50 HD105351NIDDK NIH HHS U54 DK104309NIMH NIH HHS U01 MH119690
6 · The paper itself

Abstract

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic pain disorder causing symptoms of urinary frequency, urgency, and bladder discomfort or pain. Although this condition affects a large population, little is known about its etiology. Genetic analyses of whole exome sequencing are performed on 109 individuals with IC/BPS. One family has a previously reported

Indexed as

bladdergeneticsgenitalgenomicsMendelianpainurinary

Identifiers

PMID36910591
PMCPMC10000272
OpenAlexW4310277631

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read10
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.