Evidence map›Paper›PMID 36910535›Full record

ArticleFrontiers in cardiovascular medicine2023

Biventricular circulatory support using single-device and dual-device configurations: Initial pump characterization in simulated heart failure model.

Jamshid H Karimov, Chihiro Miyagi, Christine R Flick, Anthony R Polakowski, Barry D Kuban, Taiyo Kuroda, Dennis W Horvath, Kiyotaka Fukamachi, Randall C Starling

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Technological evolution ofFrontiers in physiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jamshid H KarimovDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Chihiro MiyagiDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Christine R FlickDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Anthony R PolakowskiDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Barry D KubanDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Taiyo KurodaDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Dennis W HorvathDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Kiyotaka FukamachiDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Randall C StarlingDepartment of Cardiovascular Medicine, Miller Family Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, United States.

Funding

Self Regulating Continuous Flow Total Artificial HeartR01HL096619 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI FUKAMACHI, KIYOTAKA · 2010 to 2019
$10.9M
Advanced Ventricular Assist Device with Pulse Augmentation and Automatic Regurgitant Flow ShutoffR21HL133871 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI FUKAMACHI, KIYOTAKA · 2016 to 2017
$434k
NHLBI NIH HHS R01 HL096619NHLBI NIH HHS R21 HL133871
6 · The paper itself

Abstract

Objective: Severe biventricular heart failure (BHF) can be remedied using a biventricular assist device (BVAD). Two devices are currently in development: a universal ventricular assist device (UVAD), which will be able to assist either the left, right, or both ventricles, and a continuous-flow total artificial heart (CFTAH), which replaces the entire heart. In this study, the Methods: For this experiment, a biventricular mock circulatory loop utilizes two pneumatic pumps (Abiomed AB5000™, Danvers, MA, USA), in conjunction with a dual-output driver, to create heart failure (HF) conditions (left, LHF; right, RHF; biventricular, BHF). Systolic BHF for four different situations were replicated. In each situation, CFTAH and UVAD devices were installed and operated at two distinct speeds, and cannulations for ventricular and atrial connections were evaluated. Results: Both CFTAH and UVAD setups achieved our recommended hemodynamic criteria. The dual-UVAD arrangement yielded a better atrial balance to alleviate LHF and RHF. For moderate and severe BHF scenarios, CFTAH and dual UVADs both created excellent atrial pressure balance. Conversely, when CFTAH was atrial cannulated for LHF and RHF, the needed atrial pressure balance was not met. Conclusion: Comprehensive

Indexed as

biventricular failureblood pumpsmechanical circulatory supporttotal artificial heartuniversal deviceventricular assist device

Identifiers

PMID36910535
PMCPMC9994815

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.