ArticleFrontiers in cardiovascular medicine2023
Constipation and cardiovascular disease: A two-sample Mendelian randomization analysis.
Article in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between constipation and risk of stroke: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Systematic review of bidirectional interaction between gut microbiome, miRNAs, and human pathologies.Frontiers in microbiology · 2025Pooled it
- Identification and expression validation of key genes of Xiaozhengtongluo formula in the treatment of diabetic nephropathy by Mendelian randomization.Functional & integrative genomics · 2026Article
- Constipation and Incident Cardiovascular Disease: A Nationwide, Real-World Cohort Study.JACC. Asia · 2026Article
- Decoding the role of polyamine metabolism in lung adenocarcinoma prognosis: A triangulated approach combining transcriptome, single-cell and Mendelian randomization analyses.Oncology letters · 2026Article
- A phenome-wide hunt for risk factors of Alzheimer's disease: from metabolic clues to neuroimaging evidence.Journal of translational medicine · 2026Article
- Exploring putative links between gut microbiota and allergic rhinitis: insights from Mendelian randomization and multi-transcriptome integration.AMB Express · 2025Article
- Polysaccharide fromFrontiers in microbiology · 2025Article
- Enhancing the robustness of Mendelian randomization studies: lessons from a two-sample analysis of viral infections and colorectal cancer.Infectious agents and cancer · 2024Article
- The causal relationship between cholecystectomy and IBD/IBS and the role of bile acids and gut microbiota: a two-sample Mendelian randomization study.International journal of colorectal disease · 2024Article
- The causal relationship between gut microbiota and constipation: a two-sample Mendelian randomization study.BMC gastroenterology · 2024Article
- Bidirectional two-sample Mendelian randomization analysis identifies causal associations between cardiovascular diseases and frozen shoulder.Journal of orthopaedic surgery and research · 2024Article
- No bidirectional relationship between inflammatory bowel disease and diverticular disease: a genetic correlation and Mendelian randomization study.Frontiers in genetics · 2024Article
- Assessing the causal effects ofFrontiers in microbiology · 2024Article
- The association between constipation and stroke based on the NHANES and Mendelian randomization study.Frontiers in neuroscience · 2023Article
- Causal association between inflammatory bowel disease and herpes virus infections: a two-sample bidirectional Mendelian randomization study.Frontiers in immunology · 2023Article
- Altered gut microbial profile is associated with differentially expressed fecal microRNAs in patients with functional constipation.Frontiers in microbiology · 2023Article
- Evaluating Electrochemical Marker forIndian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Although several observational studies have suggested positive associations between constipation and cardiovascular disease (CVD), a solid causal association has not been demonstrated. Therefore, a two-sample Mendelian randomization (MR) study was performed to investigate the causal associations between constipation and CVD. Methods: Independent genetic variants strongly associated with constipation were obtained from the FinnGen consortium. Summary-level data for CVD, including coronary artery disease (CAD), myocardial infarction (MI), heart failure (HF), atrial fibrillation (AF), stroke, and its subtypes, were collected from a few extensive genome-wide association studies (GWASs). The inverse-variance weighted methods, weighted median, and MR-Egger were used for the MR estimates. The Cochran's Q test, MR-Egger intercept tests, MR-PRESSO, MR Steiger test, leave-one-out analyses, and funnel plot were used in the sensitivity analysis. Results: Genetically determined constipation was suggestively associated with AF risk (odds ratio (OR), 1.07; 95% confidence interval (CI), 1.01, 1.14; Conclusion: This MR study demonstrated suggestive causal associations of constipation on AF, despite no associations achieving a significance value after multiple testing corrections. There was no evidence of an association between constipation and the risk of CAD, MI, HF, stroke, or stroke subtypes.
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