Evidence map›Paper›PMID 36910486›Full record

ArticleFrontiers in medicine2023

Differentiating methicillin resistant and susceptible

Robert H Edgar, Anie-Pier Samson, Regis P Kowalski, John A Kellum, John Hempel, John A Viator, Vishal Jhanji

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Robert H EdgarSwanson School of Engineering, Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
Anie-Pier SamsonDepartment of Engineering, Duquesne University, Pittsburgh, PA, United States.
Regis P KowalskiSchool of Medicine and Ophthalmology, University of Pittsburgh, Pittsburgh, PA, United States.
John A KellumCenter for Central Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
John HempelDepartment of Engineering, Duquesne University, Pittsburgh, PA, United States.
John A ViatorSwanson School of Engineering, Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
Vishal JhanjiSchool of Medicine and Ophthalmology, University of Pittsburgh, Pittsburgh, PA, United States.

Funding

Photoacoustic detection, capture, and analysis of circulating melanoma cellsR01CA182840 · NCI · DUQUESNE UNIVERSITY · PI VIATOR, JOHN A. · 2014 to 2018
$1.4M
NCI NIH HHS R01 CA182840
6 · The paper itself

Abstract

Introduction: Antibiotic resistance in bacterial species constitutes a growing problem in the clinical management of infections. Not only does it limit therapeutic options, but application of ineffective antibiotics allows resistant species to progress prior to prescribing more effective treatment to patients. Methicillin resistance in Methods: We developed a photoacoustic flow cytometer using engineered bacteriophage as probes for rapid determination of methicillin resistance in Results: Using k-means clustering on the data, we achieved 100% concordance with the classification of Discussion: Photoacoustics can be used to differentiate methicillin resistant and susceptible strains of bacteria from ocular infections. This method may be generalized to other bacterial species using appropriate bacteriophages and testing for resistance using other antibiotics.

Indexed as

flow cytometryk-meansmicrobialoptoacousticsultrasonic

Identifiers

PMID36910486
PMCPMC9995766

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.