Evidence map›Paper›PMID 36910255›Full record

ArticleActa materia medica2022

MDM2-BCL-X

Mengyang Chang, Feng Gao, Jing Chen, Giri Gnawali, Wei Wang

Open access · diamondAbstract read
In one paragraph

Article in Acta materia medica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. BCL-XbioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mengyang ChangDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, USA.
Feng GaoDepartment of Pharmacology and Toxicology, University of Arizona, Tucson, Az, USA.
Jing ChenDepartment of Pharmacology and Toxicology, University of Arizona, Tucson, Az, USA.
Giri GnawaliDepartment of Pharmacology and Toxicology, University of Arizona, Tucson, Az, USA.
Wei WangDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, USA.
University of Arizona · US

Funding

Design of Fe2+ and H2O2 Induced Proximity Functionalized Imaging Probes for the Control of Cellular FunctionsR01GM130772 · NIGMS · UNIVERSITY OF ARIZONA · PI WANG, WEI · 2019 to 2022
$1.3M
NIGMS NIH HHS R01 GM130772
6 · The paper itself

Abstract

Inhibition or degradation of anti-apoptotic protein BCL-X

Indexed as

BCL-XLMDM2 E3 ligasePROTACtargeted protein degradation

Identifiers

PMID36910255
PMCPMC10004178
OpenAlexW4293490516

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.