Granzyme B Gene Polymorphisms Are Associated With Severe Non-segmental Vitiligo.

Abd El-Aziz El-Taweel, Amira Abdelrahman, Hebatallah Hegazy, Rehab Salem

Abstract read

In one paragraph

Article in The Journal of clinical and aesthetic dermatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Genetics of Vitiligo: A Review.Clinical, cosmetic and investigational dermatology · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Abd El-Aziz El-TaweelDr. El-Taweel is with Faculty of Medicine at 6th of October University in Cairo, Egypt.

Amira AbdelrahmanDrs. Abdelrahman and Salem are with the Faculty of Medicine at Benha University in Banha, Egypt.

Hebatallah HegazyDr. Hegazy is with Ministry of Health Hospital in Alexandria, Egypt.

Rehab SalemDrs. Abdelrahman and Salem are with the Faculty of Medicine at Benha University in Banha, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Granzyme B (GZMB) gene is related to human immunity and is considered as one of the genes indulged in vitiligo. Objective: To evaluate the association between GZMB (R55Q) and (P94Q) gene polymorphisms with vitiligo development in a sample of vitiligo Egyptian patients. Methods: This study was a case-control study which included 100 non-segmental vitiligo patients as well as a control group consisted of 100 healthy, sex and age matched vitiligo free individuals. The polymorphism of GZMB gene at (R55Q) and (P94A) were analyzed by polymerase chain reaction. Results: P94Q and R55Q gene polymorphisms were significantly associated with higher VASI scores. Conclusion: GZMB (Q55R) and P94A) gene polymorphisms are associated with the susceptibility to develop vitiligo in the Egyptian population and could help predicting more extensive forms of the disease.

Identifiers

PMID36909870

PMCPMC10005806

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.