ArticleFrontiers in systems biology2022
Model Integration in Computational Biology: The Role of Reproducibility, Credibility and Utility.
Article in Frontiers in systems biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Impact of combined acidic and oxidative stress on guanine DNA damage.Scientific reports · 2026Article
- Literature-derived, context-aware gene regulatory networks improve biological predictions and mathematical modeling.Bioinformatics (Oxford, England) · 2026Article
- From FAIR to CURE: guidelines for computational models of biological systems.NPJ systems biology and applications · 2026Review
- Modeling and Characterizing the Growth of the Texas-New Mexico Measles Outbreak of 2025.Epidemiologia (Basel, Switzerland) · 2025Article
- Targeting Metastasis: Exploring the Impact of Microbial Infections on Cancer Progression Through Innovative Biological Models.Current microbiology · 2025Review
- Critical Appraisal and Future Challenges of Artificial Intelligence and Anticancer Drug Development.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Artificial Intelligence and Anticancer Drug Development-Keep a Cool Head.Pharmaceutics · 2024Article
- SimService: a lightweight library for building simulation services in Python.Bioinformatics (Oxford, England) · 2024Article
- General, open-source vertex modeling in biological applications using Tissue Forge.Scientific reports · 2023Article
- General, Open-Source Vertex Modeling in Biological Applications Using Tissue Forge.Research square · 2023Article
- Modeling the disruption of respiratory disease clinical trials by non-pharmaceutical COVID-19 interventions.Nature communications · 2022Article
- Drug Development Digital Twins for Drug Discovery, Testing and Repurposing: A Schema for Requirements and Development.Frontiers in systems biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
During the COVID-19 pandemic, mathematical modeling of disease transmission has become a cornerstone of key state decisions. To advance the state-of-the-art host viral modeling to handle future pandemics, many scientists working on related issues assembled to discuss the topics. These discussions exposed the reproducibility crisis that leads to inability to reuse and integrate models. This document summarizes these discussions, presents difficulties, and mentions existing efforts towards future solutions that will allow future model utility and integration. We argue that without addressing these challenges, scientists will have diminished ability to build, disseminate, and implement high-impact multi-scale modeling that is needed to understand the health crises we face.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.