Evidence map›Paper›PMID 36909842›Full record

ArticleCurrent opinion in endocrine and metabolic research2022

Pleiotropic endophenotypic and phenotype effects of GABAergic neurosteroid synthesis deficiency in posttraumatic stress disorder.

Ann M Rasmusson, Olga Novikov, Kayla D Brown, Graziano Pinna, Suzanne L Pineles

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current opinion in endocrine and metabolic research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Ann M RasmussonVA National Center for PTSD, Women's Health Science Division, VA Boston Healthcare System, Boston, MA 02130, USA.
Olga NovikovDepartment of Psychiatry, Boston University School of Medicine, Boston, MA, 02118, USA.
Kayla D BrownDepartment of Psychiatry, Boston University School of Medicine, Boston, MA, 02118, USA.
Graziano PinnaThe Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA.
Suzanne L PinelesVA National Center for PTSD, Women's Health Science Division, VA Boston Healthcare System, Boston, MA 02130, USA.
Boston University · USVA Boston Healthcare System · USUniversity of Illinois Chicago · US

Funding

Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSDR01MH122867 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ANN M. RASMUSSON · 2020 to 2026
$3.6M
NIMH NIH HHS R01 MH122867
6 · The paper itself

Abstract

PTSD is associated with deficits in synthesis of progesterone metabolites such as allopregnanolone and pregnanolone that potently facilitate gamma-amino-butyric acid (GABA) effects at GABA

Indexed as

AllopregnanoloneDepressionGABANeurosteroidsPregnanolonePTSD

Identifiers

PMID36909842
PMCPMC10004350
OpenAlexW4281641237

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.